Researcher interests: Epigenetic regulation of pre-mRNA splicing. Understanding cellular plasticity by studying the regulatory mechanisms of alternative pre-mRNA splicing.
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: Biochemistry and Molecular Biology
Selected Publications
protein arginine methylation a prominent modification and its demethylation (2017)|
Cellular and Molecular Life Sciences|
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raf inhibitor resistance is mediated by dimerization of aberrantly spliced braf v600e ()|
Nature|
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abstract lb 428 ras independent dimerization of braf v600e splicing variants promotes resistance to raf inhibitors ()|
Cancer Research|
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identification by high throughput imaging of the histone methyltransferase ehmt2 as an epigenetic regulator of vegfa alternative splicing ()|
Nucleic Acids Research|
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inhibition of vemurafenib resistant melanoma by interference with pre mrna splicing ()|
Nature Communications|
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small molecule modulators of pre mrna splicing in cancer therapy ()|
Trends in Molecular Medicine|
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