Researcher interests: Pharmacodynamic aspects of drug delivery systems. Optimized drug delivery according to the kinetics of drug action. The effect of disease states on the kinetics of drug action and on bone resorption. Lymphatic drug absorption. Pharmacokinetics and pharmacodynamics of peptides. Structure-bioavailability of peptides.
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: School of Pharmacy- Institute for Drug Research
Selected Publications
myristoylation confers oral bioavailability and improves the bioactivity of c myd 4 4 a cyclic peptide inhibitor of myd88 (2019)|
Molecular Pharmaceutics|
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development of a novel backbone cyclic peptide inhibitor of the innate immune tlr il1r signaling protein myd88 (2018)|
Scientific Reports|
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orally active peptides is there a magic bullet (2018)|
Angewandte Chemie|
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oral aktive peptide gibt es ein patentrezept (2018)|
Angewandte Chemie|
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enhancing oral bioavailability of cyclic rgd hexa peptides by the lipophilic prodrug charge masking approach redirection of peptide intestinal permeability from paracellular to transcellular pathway (2018)|
Molecular Pharmaceutics|
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the effect of piperine pro nano lipospheres on direct intestinal phase ii metabolism the raloxifene paradigm of enhanced oral bioavailability (2018)|
Molecular Pharmaceutics|
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investigation of intestinal absorption enhancers individual vs blends with the carbamoylphosphonate js403 (2018)|
Journal of Bioequivalence & Bioavailability|
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overcoming the lack of oral availability of cyclic hexapeptides design of a selective and orally available ligand for the integrin αvβ3 (2017)|
Angewandte Chemie|
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insulin sensitizer prevents and ameliorates experimental type 1 diabetes (2017)|
American Journal of Physiology-endocrinology and Metabolism|
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backbone cyclized inhibitory peptides of myeloid differentiation factor 88 myd88 (2017)|
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carbamoylphosphonates inhibit autotaxin and metastasis formation in vivo (2015)|
Journal of Enzyme Inhibition and Medicinal Chemistry|
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carbamoylphosphonates control tumor cell proliferation and dissemination by simultaneously inhibiting carbonic anhydrase ix and matrix metalloproteinase 2 toward nontoxic chemotherapy targeting tumor microenvironment 1 (2012)|
Journal of Medicinal Chemistry|
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orally active antimetastatic nontoxic diphenyl ether derived carbamoylphosphonate matrix metalloproteinase inhibitors (2011)|
ChemMedChem|
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the effect of pro nanolipospheres pnl formulation containing natural absorption enhancers on the oral bioavailability of delta 9 tetrahydrocannabinol thc and cannabidiol cbd in a rat model ()|
European Journal of Pharmaceutical Sciences|
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piperine pro nanolipospheres as a novel oral delivery system of cannabinoids pharmacokinetic evaluation in healthy volunteers in comparison to buccal spray administration ()|
Journal of Controlled Release|
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