Researcher interests: Pharmacodynamic aspects of drug delivery systems. Optimized drug delivery according to the kinetics of drug action. The effect of disease states on the kinetics of drug action and on bone resorption. Lymphatic drug absorption. Pharmacokinetics and pharmacodynamics of peptides. Structure-bioavailability of peptides.
FACULTY / SCHOOL: School of Medicine - IMRIC

Selected Publications

adi schumacherklinger, Chaim Gilon, Amnon Hoffman, Gabriel Nussbaum, shira dishon
myristoylation confers oral bioavailability and improves the bioactivity of c myd 4 4 a cyclic peptide inhibitor of myd88 (2019)| Molecular Pharmaceutics| Read more
adi schumacher, alaa talhami, dimitrios karussis, Chaim Gilon, Amnon Hoffman, ibrahim kassis, joseph fanous, Gabriel Nussbaum, shira dishon
development of a novel backbone cyclic peptide inhibitor of the innate immune tlr il1r signaling protein myd88 (2018)| Scientific Reports| Read more
adi schumacherklinger, andreas rader, florian reichart, Chaim Gilon, Amnon Hoffman, horst kessler, michael weinmuller, shira merzbach
oral aktive peptide gibt es ein patentrezept (2018)| Angewandte Chemie| Read more
adi schumacherklinger, andreas rader, florian reichart, Chaim Gilon, Amnon Hoffman, horst kessler, michael weinmuller, shira merzbach
orally active peptides is there a magic bullet (2018)| Angewandte Chemie| Read more
adi schumacherklinger, agata gitlindomaglaska, andreas rader, florian reichart, Chaim Gilon, Amnon Hoffman, horst kessler, joseph fanous, michael weinmueller, shira merzbach
enhancing oral bioavailability of cyclic rgd hexa peptides by the lipophilic prodrug charge masking approach redirection of peptide intestinal permeability from paracellular to transcellular pathway (2018)| Molecular Pharmaceutics| Read more
Abraham Domb, dvora izgelov, gefen aldouby bier, Amnon Hoffman, irina cherniakov
the effect of piperine pro nano lipospheres on direct intestinal phase ii metabolism the raloxifene paradigm of enhanced oral bioavailability (2018)| Molecular Pharmaceutics| Read more
Eli Breuer, Amnon Hoffman, marina tsuriel, rama suresh, Reuven Reich, reut bitton
investigation of intestinal absorption enhancers individual vs blends with the carbamoylphosphonate js403 (2018)| Journal of Bioequivalence & Bioavailability| Read more
adi schumacher, andreas rader, ettore novellino, florian rechenmacher, florian reichart, francesco saverio leva, Chaim Gilon, Amnon Hoffman, horst kessler, jose munozfelix, joseph fanous, kairbaan hodivaladilke, luciana marinelli, michael weinmuller, tobias kapp, udaya kiran marelli
overcoming the lack of oral availability of cyclic hexapeptides design of a selective and orally available ligand for the integrin αvβ3 (2017)| Angewandte Chemie| Read more
Jacob Bar-Tana, Amnon Hoffman, jacob bartana, Michael Valitsky, terry unterman
insulin sensitizer prevents and ameliorates experimental type 1 diabetes (2017)| American Journal of Physiology-endocrinology and Metabolism| Read more
backbone cyclized inhibitory peptides of myeloid differentiation factor 88 myd88 (2017)| | Read more
alfonso maresca, Eli Breuer, claudiu supuran, Amnon Hoffman, Julia Frant, ofra shai, rama suresh, Reuven Reich
carbamoylphosphonates inhibit autotaxin and metastasis formation in vivo (2015)| Journal of Enzyme Inhibition and Medicinal Chemistry| Read more
Ainelly Veerendhar, alessio innocenti, alfonso maresca, Eli Breuer, claudiu supuran, Amnon Hoffman, Reuven Reich
carbamoylphosphonates control tumor cell proliferation and dissemination by simultaneously inhibiting carbonic anhydrase ix and matrix metalloproteinase 2 toward nontoxic chemotherapy targeting tumor microenvironment 1 (2012)| Journal of Medicinal Chemistry| Read more
Ainelly Veerendhar, Eli Breuer, Amnon Hoffman, Julia Frant, Olga Vaksman, Reuven Reich, Shlomo Nedvetzki, Tamir Chernilovsky
orally active antimetastatic nontoxic diphenyl ether derived carbamoylphosphonate matrix metalloproteinase inhibitors (2011)| ChemMedChem| Read more
the effect of pro nanolipospheres pnl formulation containing natural absorption enhancers on the oral bioavailability of delta 9 tetrahydrocannabinol thc and cannabidiol cbd in a rat model ()| European Journal of Pharmaceutical Sciences| Read more
piperine pro nanolipospheres as a novel oral delivery system of cannabinoids pharmacokinetic evaluation in healthy volunteers in comparison to buccal spray administration ()| Journal of Controlled Release| Read more

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