Researcher interests: RNA sensors: novel regulators of gene expression. mRNA structure and function. Translational control of eukaryotic gene expression. Regulation of mRNA splicing and the role of the RNA-activated protein kinase PKR therein. Molecular biology of immunoregulation, especially control of human cytokine (IL-2, IFN, TNF) gene expression. The cellular immune response and its dysregulation during superantigen toxic shock. Molecular biology of T cell activation by superantigens.
FACULTY / SCHOOL: School of Medicine - IMRIC
Contact Business Development: Shani Bullock
All projects by researcher: Atox-Bio Ltd

Selected Publications

farhat osman, Raymond Kaempfer, lena ilan, lise sarah namer
control of mrna splicing by noncoding intragenic rna elements that evoke a cellular stress response (2018)| The International Journal of Biochemistry & Cell Biology| Read more
bacterial superantigen toxins cd28 and drug development (2018)| Toxins| Read more
benoit masquida, farhat osman, Raymond Kaempfer, lise sarah namer, rodrigo jung, yona banai
an ancient pseudoknot in tnf α pre mrna activates pkr inducing eif2α phosphorylation that potently enhances splicing (2017)| Cell Reports| Read more
einav eliahu, farhat osman, Raymond Kaempfer, lena ilan, lise sarah namer, smadar cohenchalamish, yitzhak benasouli, yona banai
pkr activation and eif2α phosphorylation mediate human globin mrna splicing at spliceosome assembly (2017)| Cell Research| Read more
andrey popugailo, dalia hillman, Gila Arad, Raymond Kaempfer, Revital Levy, ziv rotfogel
bacterial superantigen toxins induce a lethal cytokine storm by enhancing b7 2 cd28 costimulatory receptor engagement a critical immune checkpoint (2017)| Receptors and clinical investigation| Read more
andrey popugailo, dalia hillman, emmanuelle supper, farhat osman, Gila Arad, Raymond Kaempfer, Revital Levy, ziv rotfogel
superantigens hyperinduce inflammatory cytokines by enhancing the b7 2 cd28 costimulatory receptor interaction (2016)| Proceedings of the National Academy of Sciences of the United States of America| Read more

Success Stories & related Product & PR

ATOX BIO INC.

Atox Bio is focused on the discovery and development of therapeutics for the treatment of infectious and autoimmune diseases mediated by excessive T-cell response. Having developed novel immunomodulators that reduce autoimmune response, as well...

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Contact for more information:

Shani Bullock
VP, Business Development, Healthcare
+972-2-6586608
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