Researcher interests: The laboratory of molecular modeling and drug design develops algorithms and computer techniques and employs them, as well as other computational methods, for research in structural biology, modeling, and drug design.   A central activity in the laboratory is the development of novel optimization methods for solving the complex combinatorial problems that are an integral part of structural biology and drug design. A large scope of issues has already been addressed by our core technology, called “Iterative Stochastic Elimination” (ISE) which was used to search for optimal solutions to the construction of conformational ensembles, multiple loops in proteins, protein-ligand docking, protein design, cheminformatics and others.
FACULTY / SCHOOL: School of Medicine - IMRIC

Selected Publications

anwar rayan, benny da adoosh, David Marcus, fred king, Amiram Goldblum, jianwei che
discovering highly selective and diverse ppar delta agonists by ligand based machine learning and structural modeling (2019)| Scientific Reports| Read more
Amiram Goldblum, Rivka Hadar, shayma elatawneh, shira hirsch, Joseph Tam
prediction and experimental confirmation of novelperipheral cannabinoid 1 receptor antagonists (2019)| Journal of Chemical Information and Modeling| Read more
Ahuva Cern, alexander tropsha, Yechezkel Barenholz, David Marcus, Amiram Goldblum
new drug candidates for liposomal delivery identified by computer modeling of liposomes remote loading and leakage (2017)| Journal of Controlled Release| Read more
abraham j domb, Arijit Basu, Amiram Goldblum, mohamed alyan, rachel nechushtai, yangsung sohn
discovering novel and diverse iron chelators in silico (2016)| Journal of Chemical Information and Modeling| Read more
angela mattes, anke burgerkentischer, Arijit Basu, doris finkelmeier, Amiram Goldblum, maria zatsepin, steffen rupp
computational discovery and experimental confirmation of tlr9 receptor antagonist leads (2016)| Journal of Chemical Information and Modeling| Read more
Ahuva Cern, allon e moses, ayelet michaelgayego, Yechezkel Barenholz, erez koren, Amiram Goldblum, yaelle bavli, yan q xiong
nano mupirocin enabling the parenteral activity of mupirocin (2016)| European Journal of Nanomedicine| Read more
alexander lossos, amit michaeli, berge a minassian, d sean froese, esther melaev, frank von delft, Amiram Goldblum, maria zatsepin, meitav sasi, or kakhlon, pablo v escriba, rafael alvarez, t krojer, thomas j mccorvie, w w yue
structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design (2015)| Human Molecular Genetics| Read more
Amiram Goldblum, noa stern
iterative stochastic elimination for solving complex combinatorial problems in drug discovery (2014)| Israel Journal of Chemistry| Read more
Ahuva Cern, Yechezkel Barenholz, einat nativroth, Amiram Goldblum
effect of solubilizing agents on mupirocin loading into and release from pegylated nanoliposomes (2014)| Journal of Pharmaceutical Sciences| Read more
Ahuva Cern, alexander tropsha, Yechezkel Barenholz, Amiram Goldblum
computer aided design of liposomal drugs in silico prediction and experimental validation of drug candidates for liposomal remote loading (2014)| Journal of Controlled Release| Read more

Success Stories & related Product & PR

Pepticom Ltd.

Pepticom emerged out of Prof. Amiram Goldblum laboratory in the Hebrew University in Jerusalem. Pepticom’s proprietary technology enables the design and discovery of advanced peptide-based drug candidates quickly, comprehensively and...

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Mel Larrosa
VP Business Development Healthcare
+972-2-6586692
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