Researcher interests: We use a variety of methods including evolutionary and biophysical modeling, computer simulations and bioinformatics to research fundamental biological questions. We study self-incompatibility in plant fertilization and general principles underlying the evolution and organization of gene regulatory networks. “Self-incompatibility” is a general name for molecular mechanisms, plants have developed to avoid self-fertilization, which might lead to the spread of deleterious mutations. Research of this system addresses fundamental evolutionary questions and has practical implications on crop fertilization

Selected Publications

transcriptional crosstalk varies between regulatory strategies (2018)| bioRxiv| Read more
barton, Tamar Friedlander, gasper tkacik, Roshan Prizak
evolution of new regulatory functions on biophysically realistic fitness landscapes (2017)| Nature Communications| Read more
barton, calin guet, Tamar Friedlander, gasper tkacik, Roshan Prizak
intrinsic limits to gene regulation by global crosstalk (2017)| Bulletin of the American Physical Society| Read more
barton, calin guet, Tamar Friedlander, gasper tkacik, Roshan Prizak
intrinsic limits to gene regulation by global crosstalk (2016)| Nature Communications| Read more
avraham mayo, Tamar Friedlander, Tsvi Tlusty, uri alon
evolution of bow tie architectures in biology (2015)| PLOS Computational Biology| Read more
avraham mayo, Tamar Friedlander, Tsvi Tlusty, uri alon
mutation rules and the evolution of sparseness and modularity in biological systems (2013)| PLOS ONE| Read more
asaf tal, donald court, Tamar Friedlander, joel stavans, nina costantino, rinat arbelgoren, shiri meshner
effects of post transcriptional regulation on phenotypic noise in escherichia coli (2013)| Nucleic Acids Research| Read more
Tamar Friedlander, naama brenner
adaptive response and enlargement of dynamic range (2011)| Mathematical Biosciences and Engineering| Read more
Tamar Friedlander, naama brenner
adaptive response by state dependent inactivation (2009)| Proceedings of the National Academy of Sciences of the United States of America| Read more
Tamar Friedlander, naama brenner
cellular properties and population asymptotics in the population balance equation (2008)| Physical Review Letters| Read more

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