Researcher interests: Regulation of alternative splicing; RNA editing. Structure and function of the nuclear pre-mRNA processing machine - the supraspliceosome. Pre-mRNA splicing and alternative splicing. Pre-mRNA processing. Regulation of gene expression in eukaryotes. Assembly and structural studies of biological systems. Electron microscopy.
FACULTY / SCHOOL: Faculty of Science

Selected Publications

small non coding rna within the endogenous spliceosome and alternative splicing regulation (2019)| Biochimica et Biophysica Acta| Read more
ayelet r peretz, ayub boulos, Liran Carmel, Michal Linial, shelly mahlabaviv, Ruth Sperling, tsiona eliyahu
small rna sequences derived from pre micrornas in the supraspliceosome (2018)| Nucleic Acids Research| Read more
Joseph Sperling, Ruth Sperling
structural studies of the endogenous spliceosome the supraspliceosome (2017)| Methods| Read more
the nuts and bolts of the endogenous spliceosome (2017)| Wiley Interdisciplinary Reviews - Rna| Read more
amadis pages, eduardo eyras, konstantin v korotkov, lily agranattamir, marina falaleeva, sana hidmi, Ruth Sperling, stefan stamm, yuval nevo, zaneta matuszek
dual function of c d box small nucleolar rnas in rrna modification and alternative pre mrna splicing (2016)| Proceedings of the National Academy of Sciences of the United States of America| Read more
Joseph Sperling, Ruth Sperling, yuval nevo
heat shock activates splicing at latent alternative 5 splice sites in nematodes (2015)| Nucleus| Read more
Joseph Sperling, kinneret shefer, Ruth Sperling
the supraspliceosome a multi task machine for regulated pre mrna processing in the cell nucleus (2014)| Computational and structural biotechnology journal| Read more
flavia de lima alves, hani kotzernevo, Joseph Sperling, juri rappsilber, Ruth Sperling
supraspliceosomes at defined functional states portray the pre assembled nature of the pre mrna processing machine in the cell nucleus (2014)| International Journal of Molecular Sciences| Read more
Joseph Sperling, lily agranattamir, noam shomron, Ruth Sperling
interplay between pre mrna splicing and microrna biogenesis within the supraspliceosome (2014)| Nucleic Acids Research| Read more
Joseph Sperling, miriam eisenstein, Ruth Sperling, ziv frankenstein
39 in silico study of the arrangement of the snrnps within the native spliceosome (2013)| Journal of Biomolecular Structure & Dynamics| Read more

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