Researcher interests: Regulation of alternative splicing; RNA editing. Structure and function of the nuclear pre-mRNA processing machine - the supraspliceosome. Pre-mRNA splicing and alternative splicing. Pre-mRNA processing. Regulation of gene expression in eukaryotes. Assembly and structural studies of biological systems. Electron microscopy.
FACULTY / SCHOOL: Faculty of Science
Selected Publications
small rna sequences derived from pre micrornas in the supraspliceosome (2018)|
Nucleic Acids Research|
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structural studies of the endogenous spliceosome the supraspliceosome (2017)|
Methods|
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the nuts and bolts of the endogenous spliceosome (2017)|
Wiley Interdisciplinary Reviews - Rna|
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dual function of c d box small nucleolar rnas in rrna modification and alternative pre mrna splicing (2016)|
Proceedings of the National Academy of Sciences of the United States of America|
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heat shock activates splicing at latent alternative 5 splice sites in nematodes (2015)|
Nucleus|
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the supraspliceosome a multi task machine for regulated pre mrna processing in the cell nucleus (2014)|
Computational and structural biotechnology journal|
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supraspliceosomes at defined functional states portray the pre assembled nature of the pre mrna processing machine in the cell nucleus (2014)|
International Journal of Molecular Sciences|
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interplay between pre mrna splicing and microrna biogenesis within the supraspliceosome (2014)|
Nucleic Acids Research|
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38 a network of interactions within the supraspliceosome ()|
Journal of Biomolecular Structure & Dynamics|
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39 in silico study of the arrangement of the snrnps within the native spliceosome ()|
Journal of Biomolecular Structure & Dynamics|
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