Researcher interests: The synthesis and the chemical and biological properties of novel organophosphorus compounds. The design and synthesis of novel phosphonate derivatives which influence bone metabolism and tissue calcification. The design and synthesis of new types of phosphonate prodrugs, and of new types of inhibitors of matrix metalloproteases involved in connective tissue disorders. Design and synthesis of new types of chemosensitizers for reversing multidrug resistance in hematological malignancies.
FACULTY / SCHOOL: School of Medicine - IMRIC

Selected Publications

Eli Breuer, Amnon Hoffman, marina tsuriel, rama suresh, Reuven Reich, reut bitton
investigation of intestinal absorption enhancers individual vs blends with the carbamoylphosphonate js403 (2018)| Journal of Bioequivalence & Bioavailability| Read more
alfonso maresca, Eli Breuer, claudiu supuran, Amnon Hoffman, Julia Frant, ofra shai, rama suresh, Reuven Reich
carbamoylphosphonates inhibit autotaxin and metastasis formation in vivo (2015)| Journal of Enzyme Inhibition and Medicinal Chemistry| Read more
Ainelly Veerendhar, Eli Breuer, claudiu supuran, Julia Frant, Reuven Reich, Shmuel Cohen
synthesis of enantiomeric aminoalkylcarbamoylphosphonates and their evaluation as dual action anticancer mmp and carbonic anhydrase inhibitors (2015)| Heteroatom Chemistry| Read more
Eli Breuer, claudiu supuran, Reuven Reich
chapter seventeen tumor microenvironment as target in cancer therapy (2014)| Annual Reports in Medicinal Chemistry| Read more
abstract 5065 orally active nontoxic dual mmp2 and caix inhibitors as anticancer therapy (2013)| Cancer Research| Read more
Ainelly Veerendhar, alessio innocenti, alfonso maresca, Eli Breuer, claudiu supuran, Amnon Hoffman, Reuven Reich
carbamoylphosphonates control tumor cell proliferation and dissemination by simultaneously inhibiting carbonic anhydrase ix and matrix metalloproteinase 2 toward nontoxic chemotherapy targeting tumor microenvironment 1 (2012)| Journal of Medicinal Chemistry| Read more
Ainelly Veerendhar, Eli Breuer, Amnon Hoffman, Julia Frant, Olga Vaksman, Reuven Reich, Shlomo Nedvetzki, Tamir Chernilovsky
orally active antimetastatic nontoxic diphenyl ether derived carbamoylphosphonate matrix metalloproteinase inhibitors (2011)| ChemMedChem| Read more
Eli Breuer, Efrat Harel, Abraham Rubinstein, Boaz Tirosh, weibin chen
aminoalkylcarbamoylphosphonates reduce tnf╬▒ release from activated immune cells (2010)| Bioorganic & Medicinal Chemistry Letters| Read more
Ainelly Veerendhar, Eli Breuer, Reuven Reich
phosphorus based inhibitors of matrix metalloproteinases (2010)| Comptes Rendus Chimie| Read more
appendix to nitroxides ()| | Read more

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