Researcher interests: The synthesis and the chemical and biological properties of novel organophosphorus compounds. The design and synthesis of novel phosphonate derivatives which influence bone metabolism and tissue calcification. The design and synthesis of new types of phosphonate prodrugs, and of new types of inhibitors of matrix metalloproteases involved in connective tissue disorders. Design and synthesis of new types of chemosensitizers for reversing multidrug resistance in hematological malignancies.
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: School of Pharmacy- Institute for Drug Research
Selected Publications
investigation of intestinal absorption enhancers individual vs blends with the carbamoylphosphonate js403 (2018)|
Journal of Bioequivalence & Bioavailability|
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carbamoylphosphonates inhibit autotaxin and metastasis formation in vivo (2015)|
Journal of Enzyme Inhibition and Medicinal Chemistry|
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synthesis of enantiomeric aminoalkylcarbamoylphosphonates and their evaluation as dual action anticancer mmp and carbonic anhydrase inhibitors (2015)|
Heteroatom Chemistry|
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chapter seventeen tumor microenvironment as target in cancer therapy (2014)|
Annual Reports in Medicinal Chemistry|
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abstract 5065 orally active nontoxic dual mmp2 and caix inhibitors as anticancer therapy (2013)|
Cancer Research|
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carbamoylphosphonates control tumor cell proliferation and dissemination by simultaneously inhibiting carbonic anhydrase ix and matrix metalloproteinase 2 toward nontoxic chemotherapy targeting tumor microenvironment 1 (2012)|
Journal of Medicinal Chemistry|
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orally active antimetastatic nontoxic diphenyl ether derived carbamoylphosphonate matrix metalloproteinase inhibitors (2011)|
ChemMedChem|
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aminoalkylcarbamoylphosphonates reduce tnfα release from activated immune cells (2010)|
Bioorganic & Medicinal Chemistry Letters|
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phosphorus based inhibitors of matrix metalloproteinases (2010)|
Comptes Rendus Chimie|
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appendix to nitroxides ()|
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