Researcher interests: Gene regulation in spatial and temporal decisions in the early vertebrate embryo. Genes that regulate the dorso-ventral axis of the embryo. Regulation of the anterior-posterior axis of the embryo, interactions and regulation of Vitamin-A derived signals in the early embryo. Analysis of the teratogenic effects of Vitamin A. Cloning and characterization of novel developmental genes in higher vertebrates. Homeobox genes in the establishment of the early embryonic axes.
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: Developmental Biology and Cancer Research
Selected Publications
chox cad characterization and rooster sperm preservation as a first step in the generation of transgenic chickens with modified homeobox genes (2019)|
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retinoic acid signaling reduction recapitulates the effects of alcohol on embryo size (2019)|
Genesis|
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insights into retinoic acid deficiency and the induction of craniofacial malformations and microcephaly in fetal alcohol spectrum disorder (2019)|
Genesis|
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admp controls the size of spemann s organizer through a network of self regulating expansion restriction signals (2018)|
BMC Biology|
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acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity (2018)|
Scientific Reports|
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xenopus embryos to study fetal alcohol syndrome a model for environmental teratogenesis (2018)|
Biochemistry and Cell Biology|
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special issue on fetal alcohol spectrum disorder1 (2018)|
Biochemistry and Cell Biology|
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competition between ethanol clearance and retinoic acid biosynthesis in the induction of fetal alcohol syndrome1 (2018)|
Biochemistry and Cell Biology|
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expression of the alk1 family of type i bmp admp receptors during gastrula stages in xenopus embryos (2017)|
The International Journal of Developmental Biology|
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adhfe1 a novel enzyme involved in retinoic acid dependent hox activation (2017)|
The International Journal of Developmental Biology|
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kinetic characterization and regulation of the human retinaldehyde dehydrogenase 2 enzyme during production of retinoic acid (2016)|
Biochemical Journal|
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