Researcher interests: Prof. Rubinstein's research interests are focused on site-specific therapy and real-time diagnostics of inflammation and malignant processes in the gastrointestinal (GI) tract. It includes biodegradable polymers (modified polysaccharides) colon-specific drug delivery, site specific therapy of IBD by directed nano-vehicles, mechanistic understanding of affinity processes between saccharide-containing polymers and the intestinal epithelium and optimizing multimodal therapy by remotely eroding vehicles.
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: School of Pharmacy- Institute for Drug Research
Selected Publications
synchronizing the release rates of salicylate and indomethacin from degradable chitosan hydrogel and its optimization by definitive screening design (2018)|
European Journal of Pharmaceutical Sciences|
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increasing the affinity of cationized polyacrylamide paclitaxel nanoparticles towards colon cancer cells by a surface recognition peptide (2017)|
International Journal of Pharmaceutics|
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generalizing research findings for enhanced reproducibility a translational medicine case study (2017)|
Social Science Research Network|
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the effect of linker type and recognition peptide conjugation chemistry on tissue affinity and cytotoxicity of charged polyacrylamide (2017)|
Journal of Controlled Release|
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single point mutation detection in living cancer cells by far red emitting pna fit probes (2016)|
Chemical Communications|
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a multifactorial analysis of complex pharmaceutical platforms an application of design of experiments to targetable polyacrylamide and ultrasound contrast agents (2015)|
Polymers for Advanced Technologies|
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the anti inflammatory activity of a novel fused cyclopentenone phosphonate and its potential in the local treatment of experimental colitis (2015)|
Gastroenterology Research and Practice|
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multi modal detection of colon malignancy by nir tagged recognition polymers and ultrasound contrast agents (2015)|
International Journal of Pharmaceutics|
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thermotropic behavior of celecoxib loaded beta casein micelles relevance to the improved bioavailability (2015)|
European Journal of Nanomedicine|
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aminoalkylcarbamoylphosphonates reduce tnfα release from activated immune cells (2010)|
Bioorganic & Medicinal Chemistry Letters|
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the effect of intestinal bacteria adherence on drug diffusion through solid films under stationary conditions (1997)|
Pharmaceutical Research|
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in vitro evaluation of calcium pectinate a potential colon specific drug delivery carrier (1993)|
Pharmaceutical Research|
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beta casein nanocarriers of celecoxib for improved oral bioavailability ()|
European Journal of Nanomedicine|
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