Researcher interests: Pathophysiology of brain injury - mediators of delayed neuronal damage e.g., prostaglandins, reactive oxygen species, cytokines, cannabinoids, and the cholinergic system in rat and mouse models of injury (closed head injury, CHI). Evaluation of potential therapeutic strategies. CHI as a risk factor for delayed onset of Alzheimer`s disease. Genetic manipulations (cytokines or apoE knockouts, acetylcholine-esterase transgenics, and more) as tools for investigating the role of specific mediators in traumatic brain injury. Interrelationship between traumatic brain injury and bone remodeling. Role of endocannabinoids in blood-brain barrier function and in bone remodeling after brain trauma. Mechanisms of neuroprotection induced by pre-conditioning (ischemic or heat acclimation). In vitro model for stretch injury that simulates traumatic conditions in astrocytes.
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: School of Pharmacy- Institute for Drug Research
Selected Publications
ccr5 is a therapeutic target for recovery after stroke and traumatic brain injury (2019)|
Cell|
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stimulation of n methyl d aspartate receptors by exogenous and endogenous ligands improves outcome of brain injury (2018)|
Current Opinion in Neurology|
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enhancement of brain d serine mediates recovery of cognitive function after traumatic brain injury (2018)|
Journal of Neurotrauma|
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nerve growth factor plays a role in the neurotherapeutic effect of a cd45 pan hematopoietic subpopulation derived from human umbilical cord blood in a traumatic brain injury model (2018)|
Cytotherapy|
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human umbilical cord blood cd45 pan hematopoietic cells induced a neurotherapeutic effect in mice with traumatic brain injury immunophenotyping comparison of maternal and neonatal parameters and immunomodulation (2018)|
Journal of Molecular Neuroscience|
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neuroinflammation induced memory deficits are amenable to treatment with d cycloserine (2016)|
Journal of Molecular Neuroscience|
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cannabinoids in health and disease (2016)|
Journal of basic and clinical physiology and pharmacology|
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are the endocannabinoid like compounds n acyl aminoacids neuroprotective after traumatic brain injury (2016)|
Journal of basic and clinical physiology and pharmacology|
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molecular programs induced by heat acclimation confer neuroprotection against tbi and hypoxic insults via cross tolerance mechanisms (2015)|
Frontiers in Neuroscience|
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palmitoyl serine an endogenous neuroprotective endocannabinoid like entity after traumatic brain injury (2015)|
Journal of Neuroimmune Pharmacology|
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ouabain improves functional recovery following traumatic brain injury (2014)|
Journal of Neurotrauma|
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inactivation of pkmĪ¶ in the nac shell abolished cocaine conditioned reward (2012)|
Journal of Molecular Neuroscience|
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protective effects of incensole acetate on cerebral ischemic injury (2012)|
Brain Research|
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