Researcher interests: Pathophysiology of brain injury - mediators of delayed neuronal damage e.g., prostaglandins, reactive oxygen species, cytokines, cannabinoids, and the cholinergic system in rat and mouse models of injury (closed head injury, CHI). Evaluation of potential therapeutic strategies. CHI as a risk factor for delayed onset of Alzheimer`s disease. Genetic manipulations (cytokines or apoE knockouts, acetylcholine-esterase transgenics, and more) as tools for investigating the role of specific mediators in traumatic brain injury. Interrelationship between traumatic brain injury and bone remodeling. Role of endocannabinoids in blood-brain barrier function and in bone remodeling after brain trauma. Mechanisms of neuroprotection induced by pre-conditioning (ischemic or heat acclimation). In vitro model for stretch injury that simulates traumatic conditions in astrocytes.
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: School of Pharmacy- Institute for Drug Research
Selected Publications
genetic manipulations of ccr5 and the multifaceted molecular cellular and circuit mechanisms of cognitive enhancement a cautionary tale (2019)|
IBRO Reports|
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role of cb2 receptor in the recovery of mice after traumatic brain injury (2019)|
Journal of Neurotrauma|
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ccr5 is a therapeutic target for recovery after stroke and traumatic brain injury (2019)|
Cell|
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stimulation of n methyl d aspartate receptors by exogenous and endogenous ligands improves outcome of brain injury (2018)|
Current Opinion in Neurology|
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enhancement of brain d serine mediates recovery of cognitive function after traumatic brain injury (2018)|
Journal of Neurotrauma|
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nerve growth factor plays a role in the neurotherapeutic effect of a cd45 pan hematopoietic subpopulation derived from human umbilical cord blood in a traumatic brain injury model (2018)|
Cytotherapy|
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human umbilical cord blood cd45 pan hematopoietic cells induced a neurotherapeutic effect in mice with traumatic brain injury immunophenotyping comparison of maternal and neonatal parameters and immunomodulation (2018)|
Journal of Molecular Neuroscience|
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neuroinflammation induced memory deficits are amenable to treatment with d cycloserine (2016)|
Journal of Molecular Neuroscience|
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astaxanthin a potential preconditioned neuroprotective agent to traumatic brain injury 255 board 92 june 1 9 30 am 11 00 am (2016)|
Medicine and Science in Sports and Exercise|
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cannabinoids in health and disease (2016)|
Journal of basic and clinical physiology and pharmacology|
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ouabain improves functional recovery following traumatic brain injury (2014)|
Journal of Neurotrauma|
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protective effects of incensole acetate on cerebral ischemic injury (2012)|
Brain Research|
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