Researcher interests: Biophysical studies of protein-protein interactions at the molecular level, and of the effects of mutations and post-translational modifications on these interactions; biophysical methods to identify binding sites in cancer-related proteins. “Chemical chaperones“: development of peptides and small molecules that assist in refolding of proteins whose misfolding lead to disease.
FACULTY / SCHOOL: Faculty of Science
DEPARTMENT: The Institute of Chemistry
Selected Publications
distinct g protein coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation (2019)|
Nature Communications|
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the anti apoptotic proteins naf 1 and iaspp interact to drive apoptosis in cancer cells (2019)|
Chemical Science|
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coupling multi angle light scattering to ion exchange chromatography iex mals for protein characterization (2018)|
Scientific Reports|
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protein regulation by intrinsically disordered regions a role for subdomains in the idr of the hiv 1 rev protein (2018)|
ChemBioChem|
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hiv 1 integrase derived peptides and compositions comprising them (2018)|
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wild type and cancer related p53 proteins are preferentially degraded by mdm2 as dimers rather than tetramers (2018)|
Genes & Development|
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asp133 residue in nhaa na h antiporter is required for stability cation binding and transport (2018)|
Journal of Molecular Biology|
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agonist induced dimer dissociation as a macromolecular step in g protein coupled receptor signaling (2017)|
Nature Communications|
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a combinatorial approach for the synthesis of multi phosphorylated peptides new tool for studying phosphorylation patterns in proteins (2017)|
bioRxiv|
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recombinant ostreolysin induces brown fat like phenotype in hib 1b cells (2017)|
Molecular Nutrition & Food Research|
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correction oxidation of helix 3 methionines precedes the formation of pk resistant prpsc (2017)|
PLOS Pathogens|
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peptide fibrils as monomer storage of the covalent hiv 1 integrase inhibitor (2017)|
Journal of Peptide Science|
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the ec nhaa antiporter switches from antagonistic to synergistic antiport upon a single point mutation (2016)|
Scientific Reports|
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dynamic clustering of the bacterial sensory kinase baes (2016)|
PLOS ONE|
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the disordered region of arabidopsis vip1 binds the agrobacterium vire2 protein outside its dna binding site (2014)|
Protein Engineering Design & Selection|
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frontispiece a tandem in situ peptide cyclization through trifluoroacetic acid cleavage (2014)|
Angewandte Chemie|
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a tandem in situ peptide cyclization through trifluoroacetic acid cleavage (2014)|
Angewandte Chemie|
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high resolution characterization of myosin iic protein tailpiece and its effect on filament assembly (2013)|
Journal of Biological Chemistry|
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structure activity relationship studies using peptide arrays the example of hiv 1 rev integrase interaction (2013)|
MedChemComm|
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monitoring the hiv 1 integrase enzymatic activity using atomic force microscopy in a 2ltr system (2013)|
Chemical Communications|
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peptides that inhibit hiv 1 integrase by blocking its protein protein interactions (2012)|
FEBS Journal|
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a comparative study of backbone versus side chain peptide cyclization application for hiv 1 integrase inhibitors (2012)|
Bioorganic & Medicinal Chemistry|
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