Researcher interests: Our lab investigates how gene expression is regulated in the liver and how this regulation affects liver biology.
Using genomic, metabolic and molecular biology approaches, we study the gene regulatory networks that mediate the liver’s response to nutr
FACULTY / SCHOOL: Faculty of Agricultural, Food and Environmental Quality Sciences
DEPARTMENT: Biochemistry, Food Science and Nutrition
Selected Publications
the three ds of transcription activation by glucagon direct delayed and dynamic (2018)|
Endocrinology|
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dynamic enhancer function in the chromatin context (2018)|
Wiley Interdisciplinary Reviews: Systems Biology and Medicine|
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synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading (2017)|
Nature Communications|
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abstract 5510 pro inflammatory cytokines induce synergistic gene expression by assisted loading of stat3 at a subset of primed enhancers (2017)|
Molecular and Cellular Biology, Genetics|
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bivariate genomic footprinting detects changes in transcription factor activity (2017)|
Cell Reports|
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transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response (2017)|
Genome Research|
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tm7sf3 a novel p53 regulated homeostatic factor attenuates cellular stress and the subsequent induction of the unfolded protein response (2017)|
Cell Death & Differentiation|
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steroid receptors reprogram foxa1 occupancy through dynamic chromatin transitions (2016)|
Cell|
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novel p53 target genes secreted by the liver are involved in non cell autonomous regulation (2016)|
Cell Death & Differentiation|
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transcriptional and chromatin regulation during fasting the genomic era (2015)|
Trends in Endocrinology and Metabolism|
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mutant p53r273h attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species (2012)|
Journal of Cell Science|
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