Researcher interests: Bioinorganic chemistry and medicinal chemistry. Targeting of anticancer agents. Interactions of small molecules and metal complexes with biopolymers. Toxicity of heavy metals. Inorganic coordination chemistry including synthesis, structural characterization, physical and chemical properties of transition metal complexes with potential anticancer activity.
FACULTY / SCHOOL: School of Medicine - IMRIC

Selected Publications

christian r kowol, Dan Gibson, isabella poetsch, petra heffeter, subhendu karmakar
synthesis and cytotoxicity of water soluble dual and triple action satraplatin derivatives replacement of equatorial chlorides of satraplatin by acetates (2019)| Inorganic Chemistry| Read more
alina nemirovski, Dan Gibson, maisaloon ishan, subhendu karmakar, thirumal yempala, tomer babu, valentina gandin
expanding the arsenal of ptiv anticancer agents multi action ptiv anticancer agents with bioactive ligands possessing a hydroxy functional group (2019)| Angewandte Chemie| Read more
bertrand czarny, edward kaihua chow, Dan Gibson, giorgia pastorin, lissa hooi, maria v babak, tan boon toh, wee han ang, yang zhi
dual targeting dual action platinum iv platform for enhanced anticancer activity and reduced nephrotoxicity (2019)| Angewandte Chemie| Read more
emanuele petruzzella, Dan Gibson, hana kostrhunova, jana kasparkova, janice r aldrichwright, jaroslav malina, juraj zajac, roman sirota, viktor brabec, vojtech novohradsky
a subset of new platinum antitumor agents kills cells by a multimodal mechanism of action also involving changes in the organization of the microtubule cytoskeleton (2019)| Journal of Medicinal Chemistry| Read more
emanuele petruzzella, Dan Gibson, hana kostrhunova, jana kasparkova, viktor brabec
an anticancer pt iv prodrug that acts by mechanisms involving dna damage and different epigenetic effects (2019)| Chemistry: A European Journal| Read more
multi action pt iv anticancer agents do we understand how they work (2019)| Journal of Inorganic Biochemistry| Read more
emanuele petruzzella, Dan Gibson, irene solazzo, roman sirota, valentina gandin
triple action pt iv derivatives of cisplatin a new class of potent anticancer agents that overcome resistance (2018)| Chemical Science| Read more
cristina marzano, domenico osella, Dan Gibson, ilaria zanellato, jana kasparkova, jitka pracharova, valentina gandin, viktor brabec, vojtech novohradsky
epigenetic and antitumor effects of platinum iv octanoato conjugates (2017)| Scientific Reports| Read more
aviva friedmanezra, benjamin w j harper, emanuele petruzzella, Dan Gibson, janice r aldrichwright, roman sirota
probing the interactions of cytotoxic pt 1s 2s dach 5 6 dimethyl 1 10 phenanthroline and its ptiv derivatives with human serum (2017)| ChemMedChem| Read more
benjamin w j harper, emanuele petruzzella, fernanda fabiola faccioli, Dan Gibson, janice r aldrichwright, roman sirota, valentina gandin
synthesis characterization and in vitro and in vivo anticancer activity of pt iv derivatives of pt 1s 2s dach 5 6 dimethyl 1 10 phenanthroline (2017)| Dalton Transactions| Read more
aiman abu ammar, Simon Benita, Dan Gibson, raji raveendran, taher nassar
a lipophilic pt iv oxaliplatin derivative enhances antitumor activity (2016)| Journal of Medicinal Chemistry| Read more

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