Researcher interests: DNA replication in eukaryotic cells. Enzymology of DNA replication. Protein-protein interactions; protein-DNA interactions: DNA structure. Replication origins.
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: Microbiology and Molecular Genetics
Selected Publications
trypanosoma brucei umsbp2 is a single stranded telomeric dna binding protein essential for chromosome end protection (2018)|
Nucleic Acids Research|
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the kinetoplast dna of the australian trypanosome trypanosoma copemani shares features with trypanosoma cruzi and trypanosoma lewisi (2018)|
International Journal for Parasitology|
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replication machinery of kinetoplast dna (2013)|
Trypanosomatid diseases: molecular routes to drug discovery, 2013, ISBN 9783527332557, págs. 243-260|
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exome capture reveals znf423 and cep164 mutations linking renal ciliopathies to dna damage response signaling (2012)|
Cell|
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interactions of a replication initiator with histone h1 like proteins remodel the condensed mitochondrial genome (2011)|
Journal of Biological Chemistry|
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trypanosomes have six mitochondrial dna helicases with one controlling kinetoplast maxicircle replication (2009)|
Molecular Cell|
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regulation of umsbp activities through redox sensitive protein domains (2009)|
Nucleic Acids Research|
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enzymatic mechanism controls redox mediated protein dna interactions at the replication origin of kinetoplast dna minicircles (2008)|
Journal of Biological Chemistry|
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unique characteristics of the kinetoplast dna replication machinery provide potential drug targets in trypanosomatids (2008)|
Advances in Experimental Medicine and Biology|
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mitochondrial origin binding protein umsbp mediates dna replication and segregation in trypanosomes (2007)|
Proceedings of the National Academy of Sciences of the United States of America|
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