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Prof. Rotem Karni

Researcher interests: Alternative splicing regulation in cancer. Splicing factors as a new type of oncogenes. Identification of splicing factor targets in vivo.
FACULTY / SCHOOL: School of Medicine - IMRIC
Contact Business Development: Mel Larrosa
All projects by researcher: A Novel Target for Treatment of Rare Genetic Diseases Caused by Nonsense Mutations | Decoy-Oligonucleotides Inhibiting RNA-Binding Proteins for Treatment of Cancer and other Diseases | Oligonucleotide-Based Therapy for Diagnosis and Treatment of Cancer | A Novel Therapeutic Approach Targeting Coronavirus Replication-Essential RNAs by Oligonucleotides
Cell Biology (45)Cancer (35)Genetics (26)

Selected Publications

antoine clery, erez y levanon, frederic h t allain, georgina d barnabas, gil levkowitz, Jakob Biran, Rotem Karni, maxim mogilevsky, miri danangotthold, odelia shimshon, polina denichenko, saran kumar, Tamar Geiger, thomas welte, Eylon Yavin
specific inhibition of splicing factor activity by decoy rna oligonucleotides (2019)| Nature Communications| Read more
Alberto Gabizon, alexander m binshtok, andreas leffler, asaf shilo, Ben Katz, david shneor, hagit neumannraizel, Alik Honigman, Rotem Karni, maxim mogilevsky, Shaya Lev, yoav d shaul
2 apb and cbd mediated targeting of charged cytotoxic compounds into tumor cells suggests the involvement of trpv2 channels (2019)| Frontiers in Pharmacology| Read more
amijai saragovi, Michael Berger, Ilan Stein, Rotem Karni, noam sternginossar, Eli Pikarsky, pushkar malakar, roni winkler
long noncoding rna malat1 regulates cancer glucose metabolism by enhancing mtor mediated translation of tcf7l2 (2019)| Cancer Research| Read more
elina aizenshtein, husni sharife, iddo paldor, Rotem Karni, Eli Keshet, libat barlev, maxim mogilevsky, myriam grunewald, saran kumar, Tirzah Kreisel, tomer shlomi
intra tumoral metabolic zonation and resultant phenotypic diversification are dictated by blood vessel proximity (2019)| Cell Metabolism| Read more
adi mogilevsky, florian heyd, Rotem Karni, Eli Keshet, maxim mogilevsky, odelia shimshon, saran kumar, Eylon Yavin
modulation of mknk2 alternative splicing by splice switching oligonucleotides as a novel approach for glioblastoma treatment (2018)| Nucleic Acids Research| Read more
anna feldman, chani stossel, daniel yehuda, dikla atias, eitan friedman, ella buzhor, faridah mbabaali, ilinca lungu, john m s bartlett, julie m wilson, Rotem Karni, keren cohen, maria raitsesgurevich, michael schvimer, Raanan Berger, robert e denroche, sharon halperin, stephen raskin, steven gallinger, talia golan, yulia glick
recapitulating the clinical scenario of brca associated pancreatic cancer in pre clinical models (2018)| International Journal of Cancer| Read more
alexander m binshtok, Ben Katz, Zvika Granot, janna michaeli, Rotem Karni, leonor cohendaniel, lola polyansky, maya gershkovitz, merav e shaul, rami i aqeilan, Ronit Vogt Sionov, saleh khawaled, Shaya Lev, tanya fainsodlevi, Yaki Caspi, yasuo mori, yoav d shaul, zvi g fridlender
trpm2 mediates neutrophil killing of disseminated tumor cells (2018)| Cancer Research| Read more
Rotem Karni, Zahava Siegfried
the role of alternative splicing in cancer drug resistance (2018)| Current Opinion in Genetics & Development| Read more
a maimon, d kornspan, e berger, e shaulian, hovav nechushtan, Rotem Karni, Ze'ev Paroush, r grossman, rotem lange, s anzi, t zahavi, tatyana kushnir, zeev paroush
ras ndash erk signaling induces phosphorylation of human tle1 and downregulates its repressor function (2017)| Oncogene| Read more
astridsolveig schultz, florian heyd, Rotem Karni, marco preussner, mario bunse
activation dependent traf3 exon 8 alternative splicing is controlled by celf2 and hnrnp c binding to an upstream intronic element (2017)| Molecular and Cellular Biology| Read more
adi mogilevsky, asaf shilo, hadar benyamini, Ilan Stein, kannanganattu v prasanth, Rotem Karni, Eli Pikarsky, pushkar malakar, sharona elgavish, xinying zong, yuval nevo
long noncoding rna malat1 promotes hepatocellular carcinoma development by srsf1 upregulation and mtor activation (2017)| Cancer Research| Read more
alona rabner, Ron Dzikowski, Rotem Karni, lindsey m altenhofen, manuel llinas, phil ross, shiri eshar, yael mandelgutfreund, yair fastman
pfsr1 controls alternative splicing and steady state rna levels in plasmodium falciparum through preferential recognition of specific rna motifs (2015)| Molecular Microbiology| Read more

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Mel Larrosa
VP Business Development Healthcare
+972-2-6586692
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