Researcher interests: Structural determination of biologically related macromolecules via X-ray crystallographic techniques. Ligand recognition, initial signaling events, and the role of dimer/oligomer orientation in cytokine receptor systems. Structural studies of avidin/streptavidin - biotin high affinity systems. Structural based drug design and optimization. Combinatorial approaches in drug discovery.
FACULTY / SCHOOL: Faculty of Science
Selected Publications
publisher correction coupling multi angle light scattering to ion exchange chromatography iex mals for protein characterization (2019)|
Scientific Reports|
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regulation of influenza a virus mrna splicing by clk1 (2019)|
Antiviral Research|
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generating a high valency biotin binder by selecting uniform protein assemblies via crystallization (2019)|
Crystals|
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distinctive ligand binding specificities of tandem pa14 biomass sensory elements from clostridium thermocellum and clostridium clariflavum (2019)|
Proteins|
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distinctive ligand binding specificities of tandem pa14 biomass sensory elements from clostridium thermocellum and clostridium clariflavum (2019)|
Proteins|
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nuclear erk translocation is mediated by protein kinase ck2 and accelerated by autophosphorylation (2019)|
Cellular Physiology and Biochemistry|
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coupling multi angle light scattering to ion exchange chromatography iex mals for protein characterization (2018)|
Scientific Reports|
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crystal structure of afifavidin reveals common features of molecular assemblage in the bacterial dimeric avidins (2018)|
FEBS Journal|
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retraction for plotnikov et al nuclear extracellular signal regulated kinase 1 and 2 translocation is mediated by casein kinase 2 and accelerated by autophosphorylation (2018)|
Molecular and Cellular Biology|
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tighter αc helix αl16 helix interactions seem to make p38α less prone to activation by autophosphorylation than hog1 (2016)|
Bioscience Reports|
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intrinsically active variants of erk oncogenically transform cells and disclose unexpected autophosphorylation capability that is independent of tey phosphorylation (2016)|
Molecular Biology of the Cell|
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erk2 i84a in complex with amp pnp (2016)|
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the p38β mitogen activated protein kinase possesses an intrinsic autophosphorylation activity generated by a short region composed of the α g helix and mapk insert (2014)|
Journal of Biological Chemistry|
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def pocket in p38α facilitates substrate selectivity and mediates autophosphorylation (2013)|
Journal of Biological Chemistry|
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lipid molecules induce p38α activation via a novel molecular switch (2012)|
Journal of Molecular Biology|
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p38a perifosine complex (2012)|
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the crystal structure of p38a map kinase in complex with pia24 (2012)|
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p38a pia23 complex (2012)|
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the w197a mutant of p38a map kinase (2012)|
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conformational bias imposed by source microseeds results in structural ambiguity (2011)|
Acta Crystallographica Section F-structural Biology and Crystallization Communications|
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active mutants of the tcr mediated p38α alternative activation site show changes in the phosphorylation lip and def site formation (2011)|
Journal of Molecular Biology|
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