Researcher interests: The cellular response to environmental stress and transcriptional activity that lead to proliferation and transformation.
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: Biochemistry and Molecular Biology
Selected Publications
transcription factors bind negatively selected sites within human mtdna genes (2014)|
Genome Biology and Evolution|
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molecular oncology jun proteins and ap 1 in tumorigenesis (2013)|
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metalloprotease type iii effectors that specifically cleave jnk and nf κb (2011)|
The EMBO Journal|
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mdm2 and fbw7 cooperate to induce p63 protein degradation following dna damage and cell differentiation (2010)|
Journal of Cell Science|
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ap 1 the jun proteins oncogenes or tumor suppressors in disguise (2010)|
Cellular Signalling|
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jun proteins inhibit autophagy and induce cell death (2010)|
Autophagy|
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jun proteins are starvation regulated inhibitors of autophagy (2010)|
Cancer Research|
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fumarase a mitochondrial metabolic enzyme and a cytosolic nuclear component of the dna damage response (2010)|
PLOS Biology|
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fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug induced polyploidy (2008)|
Oncogene|
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