Researcher interests: Stem cells. Diabetes. Developmental biology. Pancreatic cancer. Organ size control.
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: Developmental Biology and Cancer Research
Selected Publications
mir 17 92 and mir 106b 25 clusters regulate beta cell mitotic checkpoint and insulin secretion in mice (2019)|
Diabetologia|
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mtorc1 to ampk switching underlies β cell metabolic plasticity during maturation and diabetes (2019)|
Journal of Clinical Investigation|
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digital droplet pcr for monitoring tissue specific cell death using dna methylation patterns of circulating cell free dna (2019)|
Current Protocols in Molecular Biology|
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small extracellular vesicles are key regulators of non cell autonomous intercellular communication in senescence via the interferon protein ifitm3 (2019)|
Cell Reports|
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chip seq of plasma cell free nucleosomes identifies cell of origin gene expression programs (2019)|
bioRxiv|
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comprehensive human cell type methylation atlas reveals origins of circulating cell free dna in health and disease (2018)|
Nature Communications|
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comprehensive human cell type methylation atlas reveals origins of circulating cell free dna in health and disease (2018)|
Nature Communications|
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inhibition of mtorc1 by er stress impairs neonatal β cell expansion and predisposes to diabetes in the akita mouse (2018)|
eLife|
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beta cell dna damage response promotes islet inflammation in type 1 diabetes (2018)|
Diabetes|
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principles of dna methylation and their implications for biology and medicine (2018)|
The Lancet|
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monitoring liver damage using hepatocyte specific methylation markers in cell free circulating dna (2018)|
JCI insight|
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conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice (2017)|
Diabetologia|
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the genetic program of pancreatic β cell replication in vivo (2016)|
Diabetes|
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identification of tissue specific cell death using methylation patterns of circulating dna (2016)|
Proceedings of the National Academy of Sciences of the United States of America|
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a transgenic mouse marking live replicating cells reveals in vivo transcriptional program of proliferation (2012)|
Developmental Cell|
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