Researcher interests: Regulation of the DNA damage response. Early events in cancer development. Helicases and cancer.
FACULTY / SCHOOL: Faculty of Science
Selected Publications
essential role of brca2 in ovarian development and function (2019)|
Yearbook of Paediatric Endocrinology|
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spironolactone inhibits the growth of cancer stem cells by impairing dna damage response (2019)|
Oncogene|
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mapping global and local coevolution across 600 species to identify novel homologous recombination repair genes (2019)|
Genome Research|
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essential role of brca2 in ovarian development and function (2018)|
The New England Journal of Medicine|
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ubiquitin accumulation on disease associated protein aggregates is correlated with nuclear ubiquitin depletion histone de ubiquitination and impaired dna damage response (2017)|
PLOS ONE|
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tumor cells derived exosomes contain htert mrna and transform nonmalignant fibroblasts into telomerase positive cells (2016)|
Oncotarget|
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chromosomal instability and molecular defects in induced pluripotent stem cells from nijmegen breakage syndrome patients (2016)|
Cell Reports|
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todra a lncrna at the rad51 locus is oppositely regulated to rad51 and enhances rad51 dependent dsb double strand break repair (2015)|
PLOS ONE|
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kdm4d crosstalks with parp1 and rna at dna dsbs (2015)|
Cell Cycle|
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the dna2 nuclease helicase is an estrogen dependent gene mutated in breast and ovarian cancers (2014)|
Oncotarget|
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a high throughput chemical screen with fda approved drugs reveals that the antihypertensive drug spironolactone impairs cancer cell survival by inhibiting homology directed repair (2014)|
Nucleic Acids Research|
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fumarase a mitochondrial metabolic enzyme and a cytosolic nuclear component of the dna damage response (2010)|
PLOS Biology|
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