Researcher interests: Nucleic acid chemistry; peptide chemistry. The synthesis of chemically- modified siRNA and miRNA as therapeutic molecules. Strategies for efficient and sequence-specific DNA and RNA modifying agents. Peptide Nucleic Acid (PNA)-based molecular beacons developed as novel diagnostic tools for detecting endogenous RNA in cells and human biopsies. The potential therapeutic use of PNAs as antimalarial agents.
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: School of Pharmacy- Institute for Drug Research
Selected Publications
specific inhibition of splicing factor activity by decoy rna oligonucleotides (2019)|
Nature Communications|
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antimir 155 cyclic peptide pna conjugate synthesis cellular uptake and biological activity (2019)|
ACS Omega|
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red emitting fit pnas on site detection of rna biomarkers in fresh human cancer tissues (2019)|
Biosensors and Bioelectronics|
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mir 16 1 3p and mir 16 2 3p possess strong tumor suppressive and antimetastatic properties in osteosarcoma (2019)|
International Journal of Cancer|
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mir 16 1 3p and mir 16 2 3p possess strong tumor suppressive and antimetastatic properties in osteosarcoma (2019)|
International Journal of Cancer|
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modulation of mknk2 alternative splicing by splice switching oligonucleotides as a novel approach for glioblastoma treatment (2018)|
Nucleic Acids Research|
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reverting the molecular fingerprint of tumor dormancy as a therapeutic strategy for glioblastoma (2018)|
The FASEB Journal|
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protein regulation by intrinsically disordered regions a role for subdomains in the idr of the hiv 1 rev protein (2018)|
ChemBioChem|
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predictive model for the sequence dependent fluorogenic response of forced intercalation peptide nucleic acid (2018)|
ACS Omega|
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the effect of linker type and recognition peptide conjugation chemistry on tissue affinity and cytotoxicity of charged polyacrylamide (2017)|
Journal of Controlled Release|
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solid nano in nanoparticles for potential delivery of sirna (2017)|
Journal of Controlled Release|
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single point mutation detection in living cancer cells by far red emitting pna fit probes (2016)|
Chemical Communications|
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a multifactorial analysis of complex pharmaceutical platforms an application of design of experiments to targetable polyacrylamide and ultrasound contrast agents (2015)|
Polymers for Advanced Technologies|
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multi modal detection of colon malignancy by nir tagged recognition polymers and ultrasound contrast agents (2015)|
International Journal of Pharmaceutics|
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