Researcher interests: Joint diseases caused by cartilage degeneration. Regeneration and repair of damaged cartilage. Chromatin biology and gene expression in chondrocytes (diseased and healthy). The role of SirT1 and other chromatin-modifying enzymes in inflammatory arthritis.
FACULTY / SCHOOL: Faculty of Dental Medicine
DEPARTMENT: Institute of Dental Sciences
Selected Publications
sirt1 cleavage from cartilage degeneration to osteoarthritic biomarker (2019)|
Osteoarthritis and Cartilage|
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a predicted unstructured c terminal loop domain in sirt1 is required for cathepsin b cleavage (2018)|
Journal of Cell Science|
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lymphoid enhancer binding factor 1 mediated matrix metalloproteinase 13 gene expression is repressed by sirt1 in human chondrocytes (2018)|
Osteoarthritis and Cartilage|
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chondrocyte secretome a source of novel insights and exploratory biomarkers of osteoarthritis (2017)|
Osteoarthritis and Cartilage|
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lef1 mediated mmp13 gene expression is repressed by sirt1 in human chondrocytes (2017)|
The FASEB Journal|
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a chronic low dose of delta 9 tetrahydrocannabinol thc restores cognitive function in old mice (2017)|
Nature Medicine|
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sox9 and the many facets of its regulation in the chondrocyte lineage (2017)|
Connective Tissue Research|
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the role of sirtuins in cartilage homeostasis and osteoarthritis vol 18 43 2016 (2016)|
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acetylation reduces sox9 nuclear entry and acan gene transactivation in human chondrocytes (2016)|
Aging Cell|
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nad dependent deacetylases and medical therapy (2016)|
Medical Epigenetics|
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