Researcher interests: Structure and mechanism of neurotransmitter transporters using molecular biological, biochemical and electrophysiological approaches.
FACULTY / SCHOOL: School of Medicine - IMRIC
DEPARTMENT: Biochemistry and Molecular Biology
Selected Publications
decision letter identification of an allosteric binding site on the human glycine transporter glyt2 for bioactive lipid analgesics (2019)|
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internal gate mutants of the gaba transporter gat1 are capable of substrate exchange (2019)|
Neuropharmacology|
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both reentrant loops of the sodium coupled glutamate transporters contain molecular determinants of cation selectivity (2018)|
Journal of Biological Chemistry|
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slc6a1 variants identified in epilepsy patients reduce γ aminobutyric acid transport (2018)|
Epilepsia|
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an extra amino acid residue in transmembrane domain 10 of the γ aminobutyric acid gaba transporter gat 1 is required for efficient ion coupled transport (2017)|
Journal of Biological Chemistry|
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electrogenic steps associated with substrate binding to the neuronal glutamate transporter eaac1 (2016)|
Journal of Biological Chemistry|
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molecular determinants of substrate specificity in sodium coupled glutamate transporters (2015)|
Journal of Biological Chemistry|
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conformationally sensitive proximity of extracellular loops 2 and 4 of the γ aminobutyric acid gaba transporter gat 1 inferred from paired cysteine mutagenesis (2014)|
Journal of Biological Chemistry|
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the aromatic and charge pairs of the thin extracellular gate of the γ aminobutyric acid transporter gat 1 are differently impacted by mutation (2014)|
Journal of Biological Chemistry|
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disulfide cross linking of transport and trimerization domains of a neuronal glutamate transporter restricts the role of the substrate to the gating of the anion conductance (2014)|
Journal of Biological Chemistry|
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