Category LifeSciences and BioTechnology    Keywords epilepsy, rare disease, gene therapy Current development stage For pharmaceutical development: TRL4 - POC & Safety of candidate drug formulation is demonstrated in defined animal ...

  Category LifeSciences and BioTechnology    Keywords Parkinson’s Disease, PD, Dementia, Diagnostic Kit, Diagnostics, Non-Motor Symptoms, mRNA, Circulating RNA Current development stage General list: TRL3 Experimental proof of ...

  Category Life Sciences and Bio-Technology    Keywords Dental Biofilm, Probiotics, tooth decay, bacterial metabolism, dental caries, veterinary market Current development stage General list: TRL4 Technology validated in lab    ...

  Category Life Sciences and Biotechnology    Keywords Metabolic Syndrome, Transfer RNA fragments, Fatty liver disease, Diagnostics, Antisense oligonucleotide therapeutics, Biomarkers, Hepatic hyperlipidemia Current development stage For ...

  Category Life Sciences and Biotechnology    Keywords Ultra low dose radiation CT scanning, repeat CT scanning Current development stage For medical device: TRL3 - Hypothesis testing and initial POC is demonstrated in limited number of ...

Protein Secretion is a fundamental aspect in production of therapeutic proteins in eukaryotic cells. Most therapeutic proteins are produced as secreted proteins in mammalian cells such as CHO and HEK293.  An essential milestone in the production ...

Nir-Paz Ran, Hadassah Medical Center Background The World Health Organization has announced antibiotic resistance is one of the biggest threats to global health, food security and development today. Up to 50% of infections in G7 countries may be ...

Background Degenerative diseases become prominent with progressive ageing and thus present the most urgent biomedical challenge facing developed countries to date. One of the most prevalent musculoskeletal diseases caused during aging ...

Background Synthetic biology is the discipline of engineering application-driven biological functionalities that were not evolved by nature. Early breakthroughs of cell engineering, which were based on ectopic (over)expression of single sets of ...

Background The physical size of protein drugs and their susceptibility to degradation are key determinates that make them more dependent on drug delivery technologies. However formulating protein delivery systems so that they maintain their ...

Background   Considerable efforts have been invested in recent years in developing new, effective, yet less toxic drugs for targeted cancer therapy. Currently, this diverse group of drugs includes monoclonal antibodies, immunomodulators, ...

  Cancer research is moving into the frontiers of how to assign the correct drug(s) to a given patient. Cancer clinicians and researchers commonly search for overexpression of oncogenic biomarkers to assign a targeted treatment, but lack ...

Background To date, clinical tests that assess the level of malignancies from patient biopsies rely almost inclusively on histological analysis for specific markers and morphological cues as well as on genetic data i.e mutation analysis. In ...

  Background Solid tumors are known to continually form hypoxic microenvironments because the proliferating tumor cells grow faster than they can attract blood vessels towards them. In hypoxic microenvironments, where there is a lack of oxygen, ...

  Background Neutrophils are potent effector cells in a wide number of infectious, inflammatory and cancerous conditions. Modulation of Neutrophil functions in these conditions may have significant therapeutic benefits and effects on disease ...

  Background Current methods of tissue fixation leave much to be desired, essentially relying on technologies developed from the clothing and carpentry industries i.e. sutures, screws, and pins. Bioadhesives offer a less traumatic method of ...

  Category LifeSciences and BioTechnology    Keywords Pain, Opioid receptor, Addiction, Opioid addiction, Narcotics, AnalgesiaApplication Severe, high-impact chronic pain affects 20 million people in the US annually, and presents a common, ...

  https://elsc.huji.ac.il/faculty-staff/yosef-grodzinsky   Background Language disorders affect up to 5% of all children and account for close to 20% of children with disabilities who receive special education. Language disorders make ...