NMR Spectra Improvement of Mixtures by Enhancement of Diffusion Separation of Compounds in a Solvent

Hoffman Roy, HUJI, Faculty of Science, The Institute of Chemistry
Garti Nissim, HUJI, Faculty of Science, The Institute of Chemistry
Aserin Abraham, HUJI, Faculty of Science, The Institute of Chemistry

Innovation allows examination of molecular structure of complex mixtures


Materials, Formulations, Nuclear Magnetic Resonance Spectroscopy, NMR, DOSY, chemistry, biochemistry, analytical chemistry, pharmacy, medicine

Development Stage





  • Our state-of-the-art  liquid nanotechnology is set to revolutionize the NMR spectroscopy of mixtures
  • Uses easily available materials as well as novel formulations of specifically tailored solvent mixtures and/or novel chromatographic concepts
  • Unique application of known molecular chemical principles

Our Innovation

  • Solves the problem of examining the molecular structure of complex mixtures
  • Enhances separation using the DOSY method while maintaining the full resolution of a regular high-resolution NMR experiment.
  • Provides spectra for each component of the mixture with no need for physical separation
  • Yields the same resolution as normal high-resolution NMR

The Opportunity

  • Enables NMR analysis of simple mixtures without lengthy and expensive separation and purification
  • Eliminates separation costs for complex mixtures and provides a dramatically cheaper solution and allows previously impossible separations

Development Milestones

  • Proof of concept using model compounds and real-world examples; Development of a prototype without interfering 1H signals; Improvement of performance by adjusting composition


Patent Status

Granted US 8,633,691

Contact for more information:

Matt Zarek