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Research & Services | Antioxidants, Reactive Oxygen Species and Oxidative Stress

Kohen Ron, HUJI, School of Medicine - IMRIC, School of Pharmacy- Institute for Drug Research

Categories

Antioxidants, free radicals, reactive oxygen species (ROS), oxidative stress

 

Objective/function

  • The Antioxidants, Reactive Oxygen Species and Oxidative Stress Laboratory is active in the field of antioxidant-related research: their mechanism, natural compounds, and designing new antioxidants; hypothesis formulation on in vivo antioxidant action; network regulation; delivery enhancement; oxidative stress in the aging process; biological oxidation-reduction (redox) potential; new approaches for evaluating biological redox state; ROS-related diseases; polyphenols and their activity in vitro and in vivo, development of new methodologies, biosensors

Research provided

The laboratory is currently engaged in research in:

  • Modulation of the total antioxidant capacity of the organism by exogenous antioxidants
  • Oxidation in the gastrointestinal tract and its relevance to various diseases
  • The existence of a common mechanism for different types of stress
  • How antioxidants work in vivo
  • New approaches for quantification of the biological redox state
  • Oxidation processes in the brain and its relevance to brain pathologies
  • The mechanism of activity of polyphenols

Advantages

  • The laboratory is staffed by highly skilled, experience researchers utilizing state-of-the-art equipment and technologies

Available equipment

  • The Antioxidants, Reactive Oxygen Species and Oxidative Stress Laboratory can perform
  • Tissue cultures
  • Spectroscopy methods (E.g. Electron spin resonance, UV, Fluorescence, chemiluminescence)
  • Separation techniques
  • Cell biology techniques
  • Animal models of disease states associated with oxidation
  • In vitro simulation of biological oxidation process
  • Electrochemical techniques (E.g. voltammetric measurements)

Staff

  • Ron Kohen, PhD
  • Ran Numa (PhD candidate)
  • Meital Portugal (PhD candidate)
  • Erez Koren (PhD candidate)
  • Shlomit Gurelik (PhD candidate)
  • Esther Kanyvski (PhD candidate)

Contact

Contact for more information:

Itzik Goldwaser
VP, Head of Research Collaborations
+972-2-6586685
Contact ME:
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