Nano-Composites for Direct Light Induced Cell Stimulation

Application

Light activation of neurons is a growing field with applications ranging from basic investigation of neuronal systems to the development of new therapeutic methods. Several light activation approaches have been demonstrated using light sensitive membrane proteins. A different technique consists of using quantum dots (QDs) as artificial chromophores that can be placed at close proximity to cells and mediate electrical activation

Our Innovation

A stamping device for stamping a nanotube network onto a target substrate.

The device comprises a template structure having a support structure formed on or attached to a substrate, and a plurality of nanotubes being supported by the support structure and engaging a plane which is spatially separated from the substrate. It was demonstrated that nanoparticles could be used for light-induced activation of neurons resulting in successful neuronal stimulation

Advantages

This invention provides a novel photoelectrical device for efficient transmission of electrical signals to a neuron.

Technology

This photoelectrical device comprises one or more charging units for coupling to and stimulating one or more neurons by charge, the charging unit comprising: a nanostructure-based electrode having a surface, which has a predetermined developed surface area for coupling to a neuron and which carries a plurality of photosensitive regions (e.g. quantum dots) interfacing with a biocompatible macromolecule for tuning the relative energy levels between the photosensitive regions and the electrode, as well as for directing the spatial polarity of the charge separation the surface being thereby electrically chargeable and dischargeable in response to light excitation of the photosensitive regions, the charges stimulation of the neuron when coupled to the surface.

Opportunity

Development of retinal implant

Patent Status

Granted US 8,774,936