Cynoacrylate containing Multi-Component Polymers as Tissue Adhesives and Sealants

Cohn Daniel, HUJI, Faculty of Science, The Institute of Chemistry

Cyanoacrylate based tissues adhesive for internal use


Healthcare, Surgery

Development Stage

In vitro proof of concept; ongoing research

Patent Status

US Granted patent 12/737,920, Europe 09787558.7


Surgical Anastomosis, vast military medical use 

Tissue adhesives are used in a diversity of biomedical applications to attach tissues temporarily, until healing is completed.

In the surgical arena, adhering, rather than suturing or stapling planes of tissues, has several highly attractive features, provided it is fast-acting and assures complete closure and adhesive efficiency for the time required. The diverse uses of tissue adhesives and sealants can be exemplified by their utilization in craniofacial and facial plastic surgery, in the joining of topical skin cuts, in adhering the cornea during cataract surgery and in various vascular and gynecological applications.

Cyanoacrylates are the most important family of tissue adhesives due to their high adhesive as well as cohesive strength. Their clinical use, though, is largely limited to the skin, since until very recently, they were prohibited for internal use.


Our Innovation
The key drawbacks of cyanoacrylate tissue adhesives can’t be ignored, they have an excessively low viscosity that makes them difficult to apply, their polymerization is too fast and highly exothermic.  They are extremely rigid, their rate of degradation is excessively slow and they’re allegedly display toxicity.

·         with our technology we are able to tightly control the viscosity of the tissue adhesive at deployment time, optimize its polymerization kinetics, minimize its polymerization exothermic reaction, fine tune its mechanical properties, optimize its adhesive strength, adjust its rate of degradation and minimize its toxicity.


·         Our novel adhesives combine cyanoacrylates with other components that overcome the shortcomings of cyanoacrylates and impart the required properties to the final tissue adhesive. This is achieved by in situ co-polymerizing the cyanoacrylate with a crosslinkable biodegradable component (designated BDG) that co-polymerizes and crosslinks at the site, rendering the final tissue adhesive will the properties required.
The in situ copolymerization strategy followed is what gives it its dramatically improved chemical properties.

By controlling the chemistry, molecular weight of the biodegradable component and its ratio to the cyanoacrylate monomer, a variety of materials are produced, displaying different adhesive capabilities with different rheological and mechanical properties, covering a broad range of degradation kinetics.


  • Thanks to our ability to control the viscosity and the rate of degradation of the adhesive we can design a customized formulation for specific body tissue anastomosis thus to specific surgeries delicate as they may be.
  • In the surgical field reducing the rate of polymerization allows extended time for complicated procedures.
  • Fast strong and simple to apply adhesive for wounds in the battle field, for paramedics, and of course in emergency rooms.
  • Unlike other tissue adhesives in the market these days, the cyanoacrylate based adhesive is very fine tuned so it is suitable for use in very delicate and precise operations. 

Patent Status

Granted US 9,200,109

Contact for more information:

Mel Larrosa
VP Business Development Healthcare
Contact ME:
All projects by:Cohn Daniel (7)