Anti Biofilm Compounds for Increased Susceptibility to Antibiotics and for treatment of Acne Vulgaris

Steinberg Doron, HUJI, Faculty of Dental Medicine, Institute of Dental Sciences
(Late) Srebnik Morris, HUJI, School of Medicine - IMRIC


Current development stage              

TRL4 - POC in  relevant bacteria



There is a need to increase the susceptibility of bacteria to conventional antibiotics. The ability of bacteria to form biofilms is a significant mechanism for enhancing bacterial resistance to antibiotics. Therefore, compounds that inhibit biofilms should increase the susceptibility of certain bacterial strains to conventional therapy.

Our Innovation

  • Novel compounds with anti-biofilm activity, to be employed as a strategy for increasing bacterial susceptibility to antibiotics


  • Several novel compounds were identified and evaluated as of their ability to block biofilm formation in multiple bacterial strains such as those causing Acne vulgaris.
  • Enhanced susceptibility of bacterial biofilms to antibiotic treatment was demonstrated in various biofilm model systems.
  • Use of these novel compounds for pre-treatment during biofilm formation or for treatment of mature biofilms increased the susceptibility of certain bacterial strains towards conventional antibiotics

Expected Impact

Novel compounds have a great potential to address the unmet need of treating bacteria in biofilms by increasing the success rate of conventional antibiotic treatment.

In the specific domain of acne treatment, the developed mechanism of anti-biofilm compounds is to be used in combination with existing antibiotics and alongside other treatments. 50M people in the US alone suffer from acne, and most do not treat acne with drugs.


Contact for more information:

Mel Larrosa
VP Business Development Healthcare
Contact ME: