Novel, On Demand, RF-Triggered, Degradable Implants

Porath Danny, HUJI, Faculty of Science, The Institute of Chemistry
Shoseyov Oded, HUJI, Faculty of Agricultural, Food and Environmental Quality Sciences, Plant Sciences and Genetics
Benny Ofra , HUJI, School of Medicine - IMRIC, School of Pharmacy- Institute for Drug Research


LifeSciences and BioTechnology   


Implant, Medical Devices, Biodegradable, BioTech

Current development stage

  TRL3 Experimental proof of concept                        


  • Implant devices are extensively used, but have a few limitations:
  • Most implants remain in the body even after they finish their mission
  • Removal of implants is costly and requires an invasive procedure; only 20-30% are actually removed
  • Biodegraded implant have a pre-determined life span which may not correlate with the healing process and the medical need
  • FDA safety alert in Feb. 2011: ” Filters should be removed if possible”

Our Innovation

A novel concept in implant design which will be first applied to construct IVC filters - an “on demand” degradable implant which can be rapidly dissolved in vivo in response to external stimuli like an electro-magnetic field and after verifying by imaging that there are no trapped clots in the IVC filter.


  • Flexibility - custom made fibers with predesigned strength, elasticity, heat capacity, and diameter
  • Novelty – a new concept of RF-triggered fiber
  • Platform technology - can be used for different implants
  • Safety - biocompatible materials, no special regulatory issues are expected, non-invasive removal
  • Manufacturing - using existing methods of fabrication: coaxial extrusion and Texturing
  • Cost - inexpensive product and fewer procedures



The researchers aim to address two of the most critical problems in biomedicine: one is the precise device life span and the other is simple and immediate destruction of mal- positioned devices and implants in-vivo with minimal adverse side-effects and maximal clinical benefit to patients.   

The new procedure has two steps: filter implantation and develop a non-invasive Radio Frequency (RF) induction.

Once radio frequencies are on, iron oxide nanoparticles produce heat

Once hot, PCL/PLA will melt down for a quick core dissolution

The filter shape disintegrates within seconds

All products are biodegradable and safe.




  • IVC Filters are a unique example of a much needed degradable "on demand" Device
  • IVC filter is a medical device that is implanted into the Inferior Vena Cava to prevent life-threatening pulmonary emboli
  • One filter costs 1000$ + 10,000$ Procedure
  • Estimated annual use of 250,000 filters in the USA alone (2012) (250,000 more world-wide), half for prophylactic indications.
  • FDA approved retrievable filters in 2003

Patent Status

Published US-2017/0312388; CN 107427612

Contact for more information:

Ariela Markel
VP, Business Development, Healthcare