3193

Device for Microwave Ablation of Small Tumors in the Digestive System

Feldman Yuri, HUJI, School of Computer Science and Engineering, Applied Physics
Ben Ishai Paul, HUJI, School of Computer Science and Engineering, Applied Physics
Nahmias Yaakov, HUJI, School of Computer Science and Engineering, Bio-Engineering
Dancour Alain , Shaare Zedek Medical Center
KOCHNEV Anna
STERN Shayke, HUJI, School of Computer Science and Engineering, Computer Science
ALBERTON Joseph, Shaare Zedek Medical Center

Category

Life Sciences and Biotechnology   

Keywords

Tumor, Digestive System, Microwave, Ablation, Cancer, Radiation

Current development stage

TRL2 - Hypothesis testing and initial POC;  ex-vivo  

 

Application       

  • Very small tumors (<5mm) in gastrointestinal GI tract can hardly be detected by external means (CT, MRI, etc.) or ultrasound endoscopic examination. Stomach and liver cancers as well as pancreas are deadliest diseases of our time and countless efforts are being made in order to deal with it.  
  • Existing ablation techniques (such as Radiofrequency ablation, Ethanol ablation, Microwaves thermotherapy and Cryosurgery) are limited by tumor size, as they rely on the insertion of a needle to the tumor.  Furthermore, the possible side effects after ablation therapy include abdominal pain, infection, and bleeding into the chest cavity or abdomen.
  • This project proposes to use low power microwave radiation to ablate small, inaccessible cancerous tumors by inserting a cable or feed line with a miniature antenna array, along with an endoscope into the gastrointestinal (GI) tract. Small tumors of the GI walls or under the surface on organs like the pancreas and liver, can then be ablated away.  It is currently impossible to address such tumors.

Our Innovation

A miniature microwave antenna that could be inserted into the stomach through the working channel of an endoscope, during the examination, and used for immediate ablation in case a tumor is detected.

Advantages

  • Non-Invasive: by introducing a radiation antenna, the need for the insertion of a needle to the tumor is removed, improving the perioperative care.
  • Early stage and immediate treatment
  • Minimum collateral damage.
  • Better perioperative care by removing the need for the insertion of a needle to the tumor. 
  • Simple operating environment – no need for large power outputs (1 – 100 Mw) used today that cools the antenna's feed lines.

Technology

The proposed solution focuses the microwave radiation at the tumor and removes the cancerous tissue, by heating the cancerous cells to the temperature of cellular death, until the tumor is removed completely. The focused radiation, affecting a very thin layer of cancerous tissue with each pulse, within a confined radius, allows eliminating such a small tumor without destroying the surrounding healthy tissue.

Opportunity

  • The further development will enable application for small tumors of the GI walls or under the surface on organs like the pancreas and liver
  • The microwave ablation device will decrease the invasive treatment removing the need for painful and expensive chemotherapy or invasive surgery and will improve the morality rate.
  • Quick recovery.
  • Lower cost therapy

 

 

 

Contact for more information:

Ariela Markel
VP, Business Development, Healthcare
+972-2-6586608