Transgenic Plants with Enhanced Resistance to Plant Pathogens

Vainstein Alexander (Sasha), HUJI, Faculty of Agricultural, Food and Environmental Quality Sciences, Plant Sciences and Genetics

Transgenic Plants with Increased Resistance to Common Pathogens


Agriculture, transgenic plants, amino acid sequences, pathogen resistance, Botrytis cinerea, powdery mildew Sphaerotheca fuliginea

Development Stage

Resistance to Botrytis cinerea demonstrated  in a commercial crop






  • Demonstrates genetic constructs and amino acid sequences conferring resistance to plant pathogens, especially resistance to Botrytis cinerea, Sphaerotheca fuliginea and the viruses TMV, PVY, YLCV
  • No undesired effects when consumed: Resistance achieved by transfecting plants with sequences naturally occurring in cucumber plants or homologous genes from other plants
  • Facilitates selection of pathogen-resistant plants
  • Research demonstrates that infection on the leaves of plants with increased expression of the hetrologous sequence both in-vitro and in the growth chamber was two- to three-fold higher than in control plants
  • Resistance demonstrated in tomato plants

Our Innovation

  • Transfecting plants with a naturally occurring hetrologous sequence confers resistance to many common plant pathogens and in particular Botrytis cinerea
  • With this innovation, plants will have:
  • A smaller number of infected loci
  • A smaller area of infected loci
  • A shorter infection period
  • Longer delay before infection


The Opportunity

  • Plants with increased resistance to common pathogens

Development Milestones

  • To identify target commercial varieties and to generate transgenic plants with the constructs or to isolate homologous sequences and to use them as markers in breeding programs
  • To test rose and banana plants for the resistance to pathogens

Additional Information

  • Relevant research: Vainstein, A. et al. (2006) Spatial and temporal regulation of plastid lipid-associated protein CHRC supports its dual role. Plant Phys. 142:233-244.

Patent Status

Granted US 8,173,868

Contact for more information:

Amichai Baron
VP, Head of Business Development, Agritech & Envir