Specific Bacteria Elimination Using Bacteriophage Lysins

Ben-Yehuda Sigal, HUJI, School of Medicine - IMRIC, Microbiology and Molecular Genetics



LifeSciences and BioTechnology


Bacteriophage , Lysins

Current development stage

TRL3 Experimental proof of concept      



  • Solutions for bacterial threats ensure dairy products safety and increase shelf life.
  • Bacilli Bacteria and similar can withstand extreme temperatures, survive pasteurization and grow at low temperature, thus damage the dairy product flavor and cause its spoilage

Our Innovation

A novel approach for eradication of bacterial species using lysins; highly evolved hydrolytic enzymes produced by bacteriophages.

  • Possess high species specificity, targeting only the desired strain, leaving the commensal bacteria undamaged.
  • Destroy the peptidoglycan directly, killing both growing and non-growing stationary bacteria.
  • Target and destroy any given bacterial strain from a mixture of many different bacteria.
  • Can eradicate various strains concurrently.


  • This approach has been developed and utilized successfully in our laboratory for research purposes.
  • The Gram-positive bacterium Bacillus subtilis (B. subtilis) belongs to a unique type of bacteria, capable of altering between modes of growth and sporulation.
  • Killing specifically Bacillus subtilis grown in a mixture with other species using a purified lysin demonstrated the efficiency of our solution.


  • This approach could be used in many industrial processes, in which an elimination of a specific bacterium is required, leaving the desired bacteria unaffected.
  • Enormous potential to revolutionize the way we fight bacteria in a safe and specific manner




Contact for more information:

Amichai Baron
VP, Head of Business Development, Agritech & Envir
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