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Repurposing of Iron Chelation Drug for Wolfram Syndrome 2 and Type 2 Diabetes

Nechushtai Rachel, HUJI, Faculty of Science, The Alexander Silberman Institute for Life Sciences
Cabantchik Ioav, HUJI, Faculty of Science, The Alexander Silberman Institute for Life Sciences

 

Wolfram type 2 syndrome is a rare genetic disease associated with mitochondrial iron accumulation. A treatment by repurposing an approved iron chelator had dramatic clinical response of significant reduction of insulin dependence and other WFS2 pathologic phenotypes.

 

The treatment also resulted in a significant increase in insulin secretion in response to glucose and additional secretagogues.

 

As such, the treatment combined with additional drugs was prompted to have a positive impact for diabetic patients   

   

Contact for more information:

Ariela Markel
VP, Business Development, Healthcare
+972-2-6586608