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Iron Chelation Therapy for WFS2 and Diabetes

Cabantchik Ioav, HUJI, Faculty of Science, The Alexander Silberman Institute for Life Sciences
Nechushtai Rachel, HUJI, Faculty of Science, The Alexander Silberman Institute for Life Sciences

 

Wolfram type 2 syndrome is a rare genetic disease associated with mitochondrial iron accumulation. A treatment by repurposing an approved iron chelator had dramatic clinical response of significant reduction of insulin dependence and other WFS2 pathologic phenotypes.

 

The treatment also resulted in a significant increase in insulin secretion in response to glucose and additional secretagogues.

 

As such, the treatment combined with additional drugs was prompted to have a positive impact for diabetic patients   

   

Patent Status

Published WO2017/168414

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Ariela Markel
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