Device for Continuous Pupillary Assessment with Closed Eyelids for Neurological Conditions in Comatose Patients

Buxboim Amnon, HUJI, School of Computer Science and Engineering, Bio-Engineering
Fried Elchanan
Zilbershtein Amit, HUJI
LEVY Gahl, HUJI, Faculty of Science
Farraj Yousef, HUJI, Faculty of Science, The Institute of Chemistry
GOLDMAN Vladimir
Beatus Tsevi, HUJI, School of Computer Science and Engineering, Computer Science


Different neurological pathways can often be ascertained through the pupillary behavior. For example, early detection of neurological deterioration for traumatic brain injury (TBI), stroke and patients after brain surgeries. Currently, manual pupillary assessment protocols use penlight to evaluate pupil reactivity and a ruler to measure pupil size. In this settings, intermittent evaluation of pupils by the ICU personnel is considered standard

Our Innovation

The proposed solution is composed of light source, detector and monitoring unit and will replace the traditional, manual, pupil examination with open eyes into continuous and easy to use monitoring with closed eyelids.

Applications for use:  

Real time, continuous monitoring and detection of pupillary changes


    Monitoring through closed eyelids
  • Accurate and precise

Patent Status

Published US 2019-0282086

Contact for more information:

Mel Larrosa
VP Business Development Healthcare