4484

A Method for Improvement of Protein Production in Mammalian Cells

Tirosh Boaz, HUJI, School of Medicine - IMRIC, School of Pharmacy- Institute for Drug Research

Category

LifeSciences and BioTechnology   

Keywords

Cell line productivity, Cell line engineering, Biosimilars

Current development stage

 TRL3 - hypothesis testing and intial POC demonstrated in limited # of in-vitro models

 

Application

We suggest companies to engineer their cell line with a protein that endows cells with better growth and productivity.

Our Innovation

A new concept of vector design that incorporates a gene-specific enhanced translation elements and assess their performance in CHO cells

A single protein (oncoKIT) which improves growth and resilience to stress.

Technology

Generating stable expression of oncoKIT in production cell lines.

Opportunity

We offer companies that have their own propriety cells to use this for improvement. The proposed method to enhance protein expression has broad range of applications in R&D and biomanufacturing. The method helps to reduce the production costs and simplify the downstream processes of purification.

There is a growing demand in the field of biological drugs for improved protein expression platforms. Consequently there is a need for affordable manufacturing methods.

Contact for more information:

Ariela Markel
VP, Business Development, Healthcare
+972-2-6586608
Contact ME:
Image CAPTCHA