Naturally occurring compounds for Fighting Bacterial and Fungal Infections

Steinberg Doron, HUJI, Faculty of Dental Medicine, Institute of Dental Sciences


  • Bacteria communicate and coordinate population behavior through the mechanism of quorum sensing (QS), which controls the expression of genes that affect a variety of bacterial processes.
  • Cannabis, Cannabinoids and endo-cannabinoids can act as novel anti-microbial agents affecting pathogens both in planktonic and biofilm environments.
  • Their effect on bacterial QS has never been investigated.

Our Innovation

A novel concept for fighting bacterial and fungal infections, accumulations and pathogenicity using synthetic cannabinoids and/or human endo-cannabinoids 

Applications for use

  • Practical implications against topical infections (as dermal infections), oral infections, internal bacterial/fungal infections and infections associated with indwelling procedures (as catheters).
  • Enable the manipulation of bacterial properties that are of major importance in industry, agriculture and medicine.


  • QS Mechanism is based on small signaling molecules, termed autoinducers (AIs), which control factors such as  bioluminescence, pigment production, motility and biofilm formation, among many others.
  • The QS, free-living marine bacterium Vibrio harveyi produces and responds to at least three distinct AIs: HAI-1, AI-2 and CAI-1.   AI-2 Is referred to "universal autoinducer" as it is found in numerous Gram-positive and Gram-negative bacteria.


Patent Status

Published US 2021/0379010 A1

Contact for more information:

Ariela Markel
VP, Business Development, Healthcare
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