Meshorer Eran, HUJI, Faculty of Science, The Alexander Silberman Institute for Life Sciences
Antibody microarray monitors histone modifications for cancer and other research
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Categories |
Research/development tools, Diagnostics, Biomarkers |
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Development Stage |
Proof of concept |
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Patent Status |
provisional US patent application filed |
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Market |
Global market for biochip products was estimated at $2.6 billion in 2009, expected to increase to nearly $6 billion in 2014. Biochips currently undergoing transition from primarily research-and-development tools to applied applications in next-generation sequencing, drug discovery and development, and clinical diagnostics. |
Highlights
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High throughput antibody microarray provides epigenetic profile of histone modification in cells or tissues in one go
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Currently Western blot tests are used to determine the state of each of the dozens of different histone modifications - time consuming and labor intensive procedure
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Uses in cancer diagnosis, to monitor cancer progress, to monitor effect of drugs on cells or tissues
Our Innovation
Development Milestones
The Opportunity
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Histones have an important role in mood disorders, memory
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Histone profile changes with cancer progression – potential for cancer diagnosis
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Drugs that target histones (HDAC inhibitors) are a growing family of drugs that are beneficial for central nervous system disorders, neurodegenerative diseases, cancer and more. These arrays will enable efficient screening of the specific actions of novel and existing drugs.
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