Novel Antibiotics Derived from Frog Skin

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Technology Summary

6-2009-2281 | Novel Antibiotics Derived from Frog Skin

Mitrani Eduardo, HUJI, Faculty of Science, The Alexander Silberman Institute for Life Sciences

Natural peptides with antibacterial and antiviral properties

Categories

Peptide/Protein, Small Molecule, New Chemical Entity

Development Stage

New peptides discovered

Patent Status

Patent filed in the United States

Market

The global market for antibacterial pharmaceuticals has suffered from a major shift in sales from brand products to generics, causing revenues to drop. The growing medical problem of drug-resistant bacteria is causing many of the current antibiotics to lose efficacy. The antibiotics market is forecast to surpass $25 billion by 2011.
Highlights

Antimicrobial peptides (AMPs) are natural antibiotics that provide a first line of attack against microorganisms invading body fluids and the skin.

Several hundred such peptides have been isolated from spiders, scorpions, fruit-flies and fish, with more than 20% produced by the skin glands of frogs and toads.

Development of drug resistance fuels a constant search for new antimicrobials

Employing a proprietary method for growing intact skin glands derived from frog-skin in vitro, new peptides have been isolated
Our Innovation

Novel antimicrobial peptides isolated from the skin of various frogs.
Key Features

Non toxic to somatic cells

Powerful antiviral and antibacterial activity
Development Milestones

Next stage: synthesis of peptides and testing to determine the biological activity obtained from different combinations
The Opportunity

Seeking funding and/or collaboration for the exciting opportunity to be involved in the development of a new generation of anti-microbial drugs

Contact for more information:

Shoshana Keynan

VP, Head of Business Development, Healthcare

+972-2-6586683

All projects by:

Mitrani Eduardo (2)

Related projects (8)

Yissum Research Development Company of the Hebrew University of Jerusalem
Hi-Tech Park, Edmond J. Safra Campus, Givat-Ram, Jerusalem
P.O. Box 39135, Jerusalem 91390 Israel
Telephone: 972-2-658-6688, Fax: 972-2-658-6689

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Categories	Peptide/Protein, Small Molecule, New Chemical Entity
Development Stage	New peptides discovered
Patent Status	Patent filed in the United States
Market	The global market for antibacterial pharmaceuticals has suffered from a major shift in sales from brand products to generics, causing revenues to drop. The growing medical problem of drug-resistant bacteria is causing many of the current antibiotics to lose efficacy. The antibiotics market is forecast to surpass $25 billion by 2011.