Oxidized Cellulose Used to Prevent Allergic Reaction in Asthma, Seasonal Allergies, and Atopic Dermatitis

Shoseyov Oded, HUJI, Faculty of Agricultural, Food and Environmental Quality Sciences, Plant Sciences and Genetics
Shoseyov David, HUJI, School of Medicine - IMRIC


  • Prevention of IgE-mediated allergic reaction by blocking and clearing pollen allergens with oxidized cellulose via its polysaccharide binding domain.
  • Mode of administration: inhalation, intranasal, ocular, topical and mucosal.
  • Oxidized cellulose has a long safety track record as an invasive medical device.
  • A commercial source of GMP manufactured oxidized cellulose has been selected.
  • Easy 510(k) regulatory pathway for certain indications. 

Our Innovation

  • Oxidized cellulose, effectively prevents allergies, asthma and hay fever.
  • This is a biodegradable and biocompatible product that has exhibited a high efficiency for binding a broad-spectrum of allergens (pollen, mites, egg and cat dander).
  • The low solubility level enables it to be cleared by the mucocilliary system from the airways to the gastro-intestinal track. In addition, the oxidised cellulose, bind the allergens and prevents epithelium barrier penetration thus prevents allergic reaction..
  • The half life of oxidized cellulose is 14 days in the lungs and 55 days in the body.
  • Mouse and Rat models (in vivo and in vitro) have established oxidized cellulose powder inhalation as an effective treatment in the reduction of allergic inflammation in the lungs.
  • In-vitro assays have been developed to demonstrate mode of action and

The opportunity

  • 5 to 15% of the population in industrialized world have asthma. The prevalence and morbidity of asthmas has been on the rise, despite standard (steroids) and new treatments.
  • Asthma is the third leading cause of hospitalization among persons under the age of 18.
  • Allergy related symptoms such as atopic dermatitis and hay fever affect huge populations.

Development Milestones

  • The project is presently seeking to raise additional funding for clinical development


Patent Status

Granted US 9,095,603; Israel 194497

Contact for more information:

Keren-Or Amar
VP, Business Development, Healthcare