Entrapping Organic Bioactive Molecules within Metals

Avnir David, HUJI, Faculty of Science, The Institute of Chemistry

Promotes enhanced therapeutic or bioactive effect as well as enabling sustained release of active ingredients



Biomaterials, Water technologies, Drug delivery, New chemical entity, Medical device, Antibacterials, Topical medicine

Development Stage

Proof of concept

Patent Status

Patent application filed


Sustained-release drug delivery products estimated to reach $45.8 billion in 2014; The European industrial water treatment chemicals market is projected to reach around $1.94 billion in 2012.


  • Novel metallic composites made of therapeutic agents and metals which are either inert or therapeutically active
  • Novel composites enable slow release of therapeutic agents entrapped in therapeutic metals
  • Main result: enhanced synergistic bactericidal effect of doped silver
  • Specific application for treatment of topical conditions such as skin cancer and psoriasis

Our Innovation

Method for entrapment of bioactive molecules within metals and within bioactive metals resulting in  activity which either preserves the original action, or displays new, synergetic activity, with or without controlled release from the metal

Additional Features

  • Release rate of active ingredient can be controlled
  • Broadens the therapeutic range of the entrapped agent
  • Reduces the probability of developing resistance to entrapped agent
  • Minimizes deleterious host side-effects

Development Milestones       

Seeking funding for ongoing research and cooperation for development of specific applications

The Opportunity

  • Applications in clinical wound management and dressings
  • Can be used in preparation of medical devices and equipment to provide continuous defence against contamination.
  • Applications in therapeutic cosmetic treatments to improve appearance of diseased or wounded skin
  • Applications in air and water purification systems
  • Application in antibacterial textiles   

Patent Status

Granted US 9,289,402

Contact for more information:

Ariela Markel
VP, Business Development, Healthcare
Contact ME: