Projects related to 6-2016-4381

Results Found (49)
Technology NameBriefcaseLead Researcher
  Categories Superactive High Afinity Leptin antagonist, mutein, multiple sclerosis, inflammatory bowel syndrome, rheumatoid arthritis, fibrosis, cardiovascular disease, CKD Cachexia, Osteoarthritis Development Stage (1) In vivo tests in ...
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Gertler Arieh
  Background Mast cells (MCs) are a type of white blood cell active in the immune system. They are produced in the bone marrow and play a key role in the inflammatory process.  Additionally, they are the primary driver of allergic reactions, ...
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Levi-Schaffer Francesca
Categories Oncology, Cancer, Diagnostics Development Stage In vitro proof of concept and small animals Patent Status PCT application filed Market Cancer testing is currently one of the most important growth opportunities diagnostics ...
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Karni Rotem
Background Most cancers are unstable and highly susceptible to cell death; hence tumors represent a steady-state picture of unregulated proliferation as well as ongoing cell death. Therefore, substantial levels of tumor specific DNA may be ...
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Hellman Asaf
  Categories Diagnostics,  Research Development Stage In vitro and in-vivo proof of concept; ongoing research Patent Status US, Europe and China applications filed based on WO 2017/025968  Background Fluorescence guided surgery is currently ...
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Yavin Eylon
  Background        Very small tumors (<5mm) in gastrointestinal GI tract can hardly be detected by external means (CT, MRI, etc.) or ultrasound endoscopic examination. Stomach and liver cancers as well as pancreas are deadliest diseases ...
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Feldman Yuri
  Category Life Sciences and Biotechnology    Keywords Cathespin, Molecular Imaging, Cancer, CT, Computed Tomography, Current development stage TRL3 - Hypothesis testing and initial POC demonstrated in-vivo Application X-ray computed ...
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Blum Galia
  Categories Treatment of cancer, neurodegeneration and infectious diseases. Development Stage In vitro proof of concept; in vivo POC Patent Status PCT publication number : WO2016/142948Highlights A new technology to inhibit the activity ...
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Karni Rotem
    Background The process of cancer metastasis consists of a series of sequential events that requires deregulated proliferation and eventually distal dissemination involving detachment from the extracellular matrices and invasion of the ...
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Breuer Eli
  Background It was recently shown that enhanced expression of NAF-1, is associated with different cancers, including breast, prostate, gastric, cervical, liver, and laryngeal. Silencing of NAF-1 expression in breast, or gastric, cancer cells ...
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Nechushtai Rachel
  Background Existing methods for removing potentially tumorigenic residual pluripotent stem cells (PSCs) from differentiated cultures are based on either genetic manipulations or on cell sorting. Such processes are generally not suitable for ...
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Benvenisty Nissim
Background Epigenome editing by DNA methylation or demethylation of regulatory sequences are widely required in medicine and in biomedical research, but current technologies are non-specific and provide unpredictable effects. This technology ...
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Hellman Asaf
Dr. Sharon Merims, Hadassah Medical Center   Background Many of the anti-neoplastic tyrosine kinase inhibitors are associated with prominent and sometimes dose-limiting dermatologic complications. Of severe clinical implication are the specific ...
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Benny Ofra
 Background Glioblastoma multiforme (GBM) is a common, very aggressive brain cancer with a dismal prognosis, affecting young and middle-age adults with no effective treatment. Former efforts to diagnose glioblastoma tumors and tailor personal ...
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Hellman Asaf
Background As for today, an oral treatment to metastasis therapy is still an unmet challenge. We discovered a new approach to treat metastatic disease in that was verified in several preclinical models. Our Innovation A new approach to treat ...
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Reich Reuven
Background Cancer cells lose their epigenetic checks and balances followed by unscheduled shut-off of tumor-suppressor genes and switch-on of genes that promote cell proliferation. 1st generation of anti-cancer epigenetic drugs are ...
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Ben-Sasson Shmuel
  Category LifeSciences and BioTechnology Keywords Genomics, Cancer Resistance, Species Current development stage General list: TRL3 Experimental proof of concept             Application Mutation in specific genes or variability in ...
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Tabach Yuval
Keywords cell free DNA diagnosis, liquid biopsies, methylation patterns, histone modification Current development stage   TRL3 - hypothesis testing and intial POC demonstrated in limited # of in-vitro modelsApplication The existing sequence ...
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Friedman Nir
Category LifeSciences and BioTechnology    Keywords Therapeutic Agents, Liposomes, Biochemistry, Doxorubicin, Sulfate, Alkyl Sulfonate, DoxilTM  Application Current preclinical and clinical data indicate that there is negligible release of ...
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Barenholz Yechezkel
  Additional information will be provided upon request
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Domb Abraham
Category Life Sciences and Bio Technology    Keywords Chemotherapy, Drug resistance * The project is conducted in collaboration with Memorial Sloan-Kettering Cancer Center. Application Cells with multidrug resistance (MDR) due to aberrant ...
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Barenholz Yechezkel
      Our Innovation We found and patented that approved drugs enhance the expression of NKp30 ligand. The upregulation is persistent and does not affect cell viability. We suggest to use this new modality as a combination therapy to improve ...
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Tirosh Boaz
Category Life Sciences and Biotechnology    Keywords Carriers, Cathepsin proteases, Tetra-peptides Current development stage TRL4 - POC & Safety of candidate drug formulation is demonstrated in defined animal model Application The ...
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Blum Galia
  Background Recent reports claim that about 38% of human breast cancers may contain sequences related to MMTV. Antibodies generated against mouse lymphoma cells that harbor the virus MMTV (mouse mammary tumor virus) were used to recognize ...
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Hochman Jacob
Prof. Levy-Lahad Ephrat – Director of the Medical Genetics Institute at Shaare Zedek Hospital, Jerusalem Category LifeSciences and BioTechnology   Computer Science Keywords AI, Artificial Intelligence, Machine Learning, Digital Health, ...
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Tabach Yuval
Once-daily, sustained-release Sirolimus delivery system Categories Oral Cavity, Oncology/Cancer, Sustained Release, Drug Delivery Development Stage Prototypes tested in vitro; pharmokinetic and pharmacodynamic testing in human volunteers ...
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Friedman Michael
A novel and personalized method for identifying the optimal anti-cancer treatment, through simultaneous detection of unique tumor sensitivities to multiple drugs or drug combinations in a multiplex manner, (this can be done) in vitro on cancer ...
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Willner Itamar
Background Metal based anti-tumor therapeutics Cisplatin and Carboplatin are two of the most widely prescribed anticancer agents. However, not all tumors can be treated with Cisplatin. In addition, Cisplatin may cause an extremely toxic ...
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Tshuva Edit
  Category Life Sciences and Bio Technology    Keywords new contrast agent, imaging, mammography, tumor, visual detection, sentinel lymph node, liposomesApplication Liposomal formulation with a new moiety having very high loading of the ...
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Golomb Gershon
Background   Considerable efforts have been invested in recent years in developing new, effective, yet less toxic drugs for targeted cancer therapy. Currently, this diverse group of drugs includes monoclonal antibodies, immunomodulators, ...
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Galski- Lorberboum Haya