Projects related to 6-2018-4559

Results Found (24)
Technology NameBriefcaseLead Researcher
Background Fatty liver disease - Non alcoholic fatty liver disease (NAFLD) is  a continuum of diseases that include simple steatosis and non-alcoholic steatohepatitis (NASH) ultimately leading to cirrhosis, hepatocellular carcinoma (HCC) and/or ...
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Tirosh Oren
  Background Many important biochemical compounds and drugs of natural origin contain spirofuranone ring structures (these structures exist among carbohydrates, terpenoids, vitamins, alkaloids, glycosides and antibiotics). All derived from a ...
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Tsvelikhovsky Dmitry
  Background Oxazine, Azaspirone, Quinolines, Quinolinone, and Quinolinol structures are frequently observed as scaffold segments in various biochemical compounds. These architectures have been identified as building blocks of a numerous ...
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Tsvelikhovsky Dmitry
  Background Methylene lactone structures are frequently observed as scaffold segments of various biochemical compounds. These architectures have been identified as building blocks of numerous terpenoids, as well as other families of diverse ...
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Tsvelikhovsky Dmitry
Background As for today, an oral treatment to metastasis therapy is still an unmet challenge. We discovered a new approach to treat metastatic disease in that was verified in several preclinical models. Our Innovation A new approach to treat ...
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Reich Reuven
  Categories Small molecules, anti-inflammatory treatment Development Stage In-vivo proof of concept Patent Status Patent application filed Market Inflammation indications: acute pancreatitis, acute live damage, fatty liver damage, ...
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Weinstock-Rosin Marta
Background Cancer cells lose their epigenetic checks and balances followed by unscheduled shut-off of tumor-suppressor genes and switch-on of genes that promote cell proliferation. 1st generation of anti-cancer epigenetic drugs are ...
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Ben-Sasson Shmuel
  Categories: Life sciences & Biotechnology Technology Keywords: Muscular dystrophy, nonsense mutation, Duchenne, Becker, cystic fibrosis, genetic diseases, dystrophin   Development Stage: Proof of concept  Our Innovation A nonsense ...
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Karni Rotem
  Additional information will be provided upon request
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Domb Abraham
Category Life Sciences and Bio Technology    Keywords Iterative Stochastic Elimination (ISE), Ligands, TLRs Current development stage TRL3 - hypothesis testing and intial POC demonstrated in limited # of in-vitro ...
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Goldblum Amiram
Background Age Related Macular Degeneration (AMD) is the leading cause of blindness in elderlies in the western world and an increasingly growing problem. The global AMD and diabetic retinopathy treatment market is overwhelmingly dominated by ...
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Benny Ofra
  Background Neuro-protective drugs products of all types protect the brain and peripheral nervous system neurons from degeneration and injury by promoting neuronal survival, proliferation and differentiation. These products can be used in the ...
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Tsvelikhovsky Dmitry
  Category Life Sciences ,pharma Keywords Non-alcoholic fatty liver disease, NAFLD, Liver Toxicity, metabolic diseases, Current development stage General list: TRL3 Experimental proof of concept              Partnership ...
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Tirosh Oren
  Category Metabolic diseases Keywords Abdominal obesity, obesity Current development stage Pharmaceutical development: TRL2  Hypothesis Formulated        Collaboration Opportunity Sponsored Research with an option to License Research ...
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Monsonego-Ornan Efrat
Delivers treatment in response to pH conditions in mouth   Categories Coatings, Biomaterials, Polymers, Composites, Dental Care Development Stage Successful clinical trials – ready for commercialization Patent Status Patent ...
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Friedman Michael
  Background Current methods of tissue fixation leave much to be desired, essentially relying on technologies developed from the clothing and carpentry industries i.e. sutures, screws, and pins. Bioadhesives offer a less traumatic method of ...
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Mandler Daniel
Keywords Drug Delivery, Formulation Current development stage TRL7, Prototype and proprietary list of approved drugs that benefit from liposomal formulationsApplication Most active pharmaceutical ingredients (APIs) are not suitable for ...
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Goldblum Amiram
Additional information will be provided upon request
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Avraham Yosefa
Keywords Nanoparticles, Neuropeptides, Intranasal delivery Current development stage TRL4 - POC & Safety of candidate drug formulation is demonstrated in defined animal model Highlights Emulsification in aqueous media is not effective ...
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Domb Abraham
Background  Micro-emulsions are formed more or less spontaneously when their components are brought into contact.  They have been the only successful delivery systems for certain types of pharmaceutical compounds, particularly compounds such as ...
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Domb Abraham
Background        Many of today’s leading compounds and drugs in pipeline fail to reach clinical stages due to poor oral bioavailability. In addition, Increase in oral bioavailability leads a lower inter and intra subject variability. Our ...
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Domb Abraham
  Additional information will be provided upon request
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Domb Abraham
Category Life Sciences and Bio Technology    Keywords Chemotherapy, Drug resistance * The project is conducted in collaboration with Memorial Sloan-Kettering Cancer Center. Application Cells with multidrug resistance (MDR) due to aberrant ...
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Barenholz Yechezkel
Background Peptides are key players in a variety of physiological and pathological processes and play very important roles in modulating various cell functions. One of the most important challenges developing peptide drugs is the lack of ...
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Gilon Chaim