Projects related to 6-2017-4471

Results Found (65)
Technology NameBriefcaseLead Researcher
Background Fatty liver disease - Non alcoholic fatty liver disease (NAFLD) is  a continuum of diseases that include simple steatosis and non-alcoholic steatohepatitis (NASH) ultimately leading to cirrhosis, hepatocellular carcinoma (HCC) and/or ...
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Tirosh Oren
  Background Many important biochemical compounds and drugs of natural origin contain spirofuranone ring structures (these structures exist among carbohydrates, terpenoids, vitamins, alkaloids, glycosides and antibiotics). All derived from a ...
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Tsvelikhovsky Dmitry
  Our Innovation   Based on a provocative working hypothesis, we most probably identified the molecular origin of insulin resistance (IR). Systemic IR is induced via post-translational modification (PTM) of liver key regulatory proteins. We ...
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Ben-Sasson Shmuel
  Background Oxazine, Azaspirone, Quinolines, Quinolinone, and Quinolinol structures are frequently observed as scaffold segments in various biochemical compounds. These architectures have been identified as building blocks of a numerous ...
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Tsvelikhovsky Dmitry
  Background Methylene lactone structures are frequently observed as scaffold segments of various biochemical compounds. These architectures have been identified as building blocks of numerous terpenoids, as well as other families of diverse ...
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Tsvelikhovsky Dmitry
Background As for today, an oral treatment to metastasis therapy is still an unmet challenge. We discovered a new approach to treat metastatic disease in that was verified in several preclinical models. Our Innovation A new approach to treat ...
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Reich Reuven
  Background Malaria is caused by unicellular Plasmodium parasites which are transmitted by the bite of mosquitoes. Although several medicines are available for prophylaxis and treatment of acute infection, their application is severely hampered ...
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Dzikowski Ron
  Background Neuro-protective drugs products of all types protect the brain and peripheral nervous system neurons from degeneration and injury by promoting neuronal survival, proliferation and differentiation. These products can be used in the ...
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Tsvelikhovsky Dmitry
Wide range of disorders including inflammation, pain, neurological and neurodegenerative diseases, MS, cancer Categories Immunology, Inflammation, CNS, Cardiovascular, Small Molecule Development Stage Tested in head injury small animal ...
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Mechoulam Raphael
Background Metal based anti-tumor therapeutics Cisplatin and Carboplatin are two of the most widely prescribed anticancer agents. However, not all tumors can be treated with Cisplatin. In addition, Cisplatin may cause an extremely toxic ...
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Tshuva Edit
Category Chemistry & Materials    Keywords VPA, Epilepsy, Neuropathic Pain and Bipolar Disorder Current development stage TRL 4, POC demonstrated, anticonvulsant activity tested in animal modelsApplication Prolonged epileptic ...
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Bialer Meir
Background Valproic acid (VPA) is a first line antiepileptic and CNS drug (Epilepsy, neuropathic pain, bipolar disorders etc) Multivalent action of VPA is highly advantageous, promising improved efficacy with reduced side effects for ...
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Bialer Meir
Background: Autism spectrum disorder (ASD) is one of the fastest growing developmental disability in the United States, represents a group of neurodevelopmental disorders characterized by impaired social interaction and communication as well as ...
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Avraham Yosefa
  Category Life Sciences and Biotechnology    Keywords Bipolar disease, Migraine, Schizophrenia, Epilepsy & Neuropathic Pain, antiepileptics, drugs (AEDs), CNS drugs Current development stage TRL7- Phase 2 clinical trials ...
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Bialer Meir
Keywords Nanoparticles, Neuropeptides, Intranasal delivery Current development stage TRL4 - POC & Safety of candidate drug formulation is demonstrated in defined animal model Highlights Emulsification in aqueous media is not effective ...
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Domb Abraham
Categories: Life Science & Biotechnology Technology Keywords: Nasal administration, CNS active oil,  neurodegenerative diseases, CNS Development Stage: Formulation and experiments in animals Patent Status: US  patent application ...
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Touitou Elka
Keywords Cell death, dopaminergic (DA) neurons, L-Dopa-induced dyskinesia (LID) Current development stage TRL3 - hypothesis testing and initial POC demonstrated in limited number of in-vitro models Application Parkinson’s Disease (PD) is a ...
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Atlas Daphne
Keywords Parkinson’s disease, PD, Central Nervous System, CNS Current development stage TRL3 - Hypothesis testing and intial POC demonstrated in limited number of in-vitro models;  Our Innovation Parkinson disease (PD) is a long-term, ...
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Sharon Ronit
  Categories Superactive High Afinity Leptin antagonist, mutein, multiple sclerosis, inflammatory bowel syndrome, rheumatoid arthritis, fibrosis, cardiovascular disease, CKD Cachexia, Osteoarthritis Development Stage (1) In vivo tests in ...
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Gertler Arieh
  Background Mast cells (MCs) are a type of white blood cell active in the immune system. They are produced in the bone marrow and play a key role in the inflammatory process.  Additionally, they are the primary driver of allergic reactions, ...
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Levi-Schaffer Francesca
Categories Oncology, Cancer, Diagnostics Development Stage In vitro proof of concept and small animals Patent Status PCT application filed Market Cancer testing is currently one of the most important growth opportunities diagnostics ...
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Karni Rotem
Background Most cancers are unstable and highly susceptible to cell death; hence tumors represent a steady-state picture of unregulated proliferation as well as ongoing cell death. Therefore, substantial levels of tumor specific DNA may be ...
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Hellman Asaf
  Categories Diagnostics,  Research Development Stage In vitro and in-vivo proof of concept; ongoing research Patent Status US, Europe and China applications filed based on WO 2017/025968  Background Fluorescence guided surgery is currently ...
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Yavin Eylon
  Background        Very small tumors (<5mm) in gastrointestinal GI tract can hardly be detected by external means (CT, MRI, etc.) or ultrasound endoscopic examination. Stomach and liver cancers as well as pancreas are deadliest diseases ...
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Feldman Yuri
  Category Life Sciences and Biotechnology    Keywords Cathespin, Molecular Imaging, Cancer, CT, Computed Tomography, Current development stage TRL3 - Hypothesis testing and initial POC demonstrated in-vivo Application X-ray computed ...
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Blum Galia
  Categories Treatment of cancer, neurodegeneration and infectious diseases. Development Stage In vitro proof of concept; in vivo POC Patent Status PCT publication number : WO2016/142948Highlights A new technology to inhibit the activity ...
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Karni Rotem
    Background The process of cancer metastasis consists of a series of sequential events that requires deregulated proliferation and eventually distal dissemination involving detachment from the extracellular matrices and invasion of the ...
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Breuer Eli
  Background It was recently shown that enhanced expression of NAF-1, is associated with different cancers, including breast, prostate, gastric, cervical, liver, and laryngeal. Silencing of NAF-1 expression in breast, or gastric, cancer cells ...
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Nechushtai Rachel