Projects related to 6-2018-4545

Results Found (34)
Technology NameBriefcaseLead Researcher
Background Fatty liver disease - Non alcoholic fatty liver disease (NAFLD) is  a continuum of diseases that include simple steatosis and non-alcoholic steatohepatitis (NASH) ultimately leading to cirrhosis, hepatocellular carcinoma (HCC) and/or ...
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Tirosh Oren
  Background Many important biochemical compounds and drugs of natural origin contain spirofuranone ring structures (these structures exist among carbohydrates, terpenoids, vitamins, alkaloids, glycosides and antibiotics). All derived from a ...
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Tsvelikhovsky Dmitry
  Our Innovation   Based on a provocative working hypothesis, we most probably identified the molecular origin of insulin resistance (IR). Systemic IR is induced via post-translational modification (PTM) of liver key regulatory proteins. We ...
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Ben-Sasson Shmuel
  Background Oxazine, Azaspirone, Quinolines, Quinolinone, and Quinolinol structures are frequently observed as scaffold segments in various biochemical compounds. These architectures have been identified as building blocks of a numerous ...
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Tsvelikhovsky Dmitry
  Background Methylene lactone structures are frequently observed as scaffold segments of various biochemical compounds. These architectures have been identified as building blocks of numerous terpenoids, as well as other families of diverse ...
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Tsvelikhovsky Dmitry
Background As for today, an oral treatment to metastasis therapy is still an unmet challenge. We discovered a new approach to treat metastatic disease in that was verified in several preclinical models. Our Innovation A new approach to treat ...
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Reich Reuven
  Background Malaria is caused by unicellular Plasmodium parasites which are transmitted by the bite of mosquitoes. Although several medicines are available for prophylaxis and treatment of acute infection, their application is severely hampered ...
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Dzikowski Ron
  Additional information will be provided upon request
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Domb Abraham
Wide range of disorders including inflammation, pain, neurological and neurodegenerative diseases, MS, cancer Categories Immunology, Inflammation, CNS, Cardiovascular, Small Molecule Development Stage Tested in head injury small animal ...
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Mechoulam Raphael
Background Metal based anti-tumor therapeutics Cisplatin and Carboplatin are two of the most widely prescribed anticancer agents. However, not all tumors can be treated with Cisplatin. In addition, Cisplatin may cause an extremely toxic ...
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Tshuva Edit
Category Chemistry & Materials    Keywords VPA, Epilepsy, Neuropathic Pain and Bipolar Disorder Current development stage TRL 4, POC demonstrated, anticonvulsant activity tested in animal modelsApplication Prolonged epileptic ...
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Bialer Meir
Background Valproic acid (VPA) is a first line antiepileptic and CNS drug (Epilepsy, neuropathic pain, bipolar disorders etc) Multivalent action of VPA is highly advantageous, promising improved efficacy with reduced side effects for ...
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Bialer Meir
Background: Autism spectrum disorder (ASD) is one of the fastest growing developmental disability in the United States, represents a group of neurodevelopmental disorders characterized by impaired social interaction and communication as well as ...
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Avraham Yosefa
  Category Life Sciences and Biotechnology    Keywords Bipolar disease, Migraine, Schizophrenia, Epilepsy & Neuropathic Pain, antiepileptics, drugs (AEDs), CNS drugs Current development stage TRL7- Phase 2 clinical trials ...
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Bialer Meir
Keywords Nanoparticles, Neuropeptides, Intranasal delivery Current development stage TRL4 - POC & Safety of candidate drug formulation is demonstrated in defined animal model Highlights Emulsification in aqueous media is not effective ...
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Domb Abraham
Categories: Life Science & Biotechnology Technology Keywords: Nasal administration, CNS active oil,  neurodegenerative diseases, CNS Development Stage: Formulation and experiments in animals Patent Status: US  patent application ...
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Touitou Elka
Keywords Cell death, dopaminergic (DA) neurons, L-Dopa-induced dyskinesia (LID) Current development stage TRL3 - hypothesis testing and initial POC demonstrated in limited number of in-vitro models Application Parkinson’s Disease (PD) is a ...
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Atlas Daphne
Keywords Parkinson’s disease, PD, Central Nervous System, CNS Current development stage TRL3 - Hypothesis testing and intial POC demonstrated in limited number of in-vitro models;  Our Innovation Parkinson disease (PD) is a long-term, ...
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Sharon Ronit
  Categories Small molecules, anti-inflammatory treatment Development Stage In-vivo proof of concept Patent Status Patent application filed Market Inflammation indications: acute pancreatitis, acute live damage, fatty liver damage, ...
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Weinstock-Rosin Marta
Background Cancer cells lose their epigenetic checks and balances followed by unscheduled shut-off of tumor-suppressor genes and switch-on of genes that promote cell proliferation. 1st generation of anti-cancer epigenetic drugs are ...
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Ben-Sasson Shmuel
  Categories: Life sciences & Biotechnology Technology Keywords: Muscular dystrophy, nonsense mutation, Duchenne, Becker, cystic fibrosis, genetic diseases, dystrophin   Development Stage: Proof of concept  Our Innovation A nonsense ...
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Karni Rotem
  Additional information will be provided upon request
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Domb Abraham
  Additional information will be provided upon request
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Domb Abraham