| Technology Name | Briefcase | Lead Researcher |
|---|---|---|
Background
Fatty liver disease - Non alcoholic fatty liver disease (NAFLD) is a continuum of diseases that include simple steatosis and non-alcoholic steatohepatitis (NASH) ultimately leading to cirrhosis, hepatocellular carcinoma (HCC) and/or ... More | Tirosh Oren | |
Background
Many important biochemical compounds and drugs of natural origin contain spirofuranone ring structures (these structures exist among carbohydrates, terpenoids, vitamins, alkaloids, glycosides and antibiotics). All derived from a ... More | Tsvelikhovsky Dmitry | |
Our Innovation
Based on a provocative working hypothesis, we most probably identified the molecular origin of insulin resistance (IR). Systemic IR is induced via post-translational modification (PTM) of liver key regulatory proteins. We ... More | Ben-Sasson Shmuel | |
Background
Oxazine, Azaspirone, Quinolines, Quinolinone, and Quinolinol structures are frequently observed as scaffold segments in various biochemical compounds. These architectures have been identified as building blocks of a numerous ... More | Tsvelikhovsky Dmitry | |
Background
Methylene lactone structures are frequently observed as scaffold segments of various biochemical compounds.
These architectures have been identified as building blocks of numerous terpenoids, as well as other families of diverse ... More | Tsvelikhovsky Dmitry | |
Background
As for today, an oral treatment to metastasis therapy is still an unmet challenge. We discovered a new approach to treat metastatic disease in that was verified in several preclinical models.
Our Innovation
A new approach to treat ... More | Reich Reuven | |
Background
Malaria is caused by unicellular Plasmodium parasites which are transmitted by the bite of mosquitoes. Although several medicines are available for prophylaxis and treatment of acute infection, their application is severely hampered ... More | Dzikowski Ron | |
Additional information will be provided upon request
More | Domb Abraham | |
Background
Agonists that bind well to the cannabinoid CB2 receptor and do not bind, or only bind weakly to the cannabinoid CB1 receptor are very promising therapeutic compounds for a wide range of disorders.
CB1 agonists (such as the ... More | Mechoulam Raphael | |
New Ti(IV) metal complexes of Salan-ligands for Cancer treatment with reduce side effects (No. 2497)
Background
Metal based anti-tumor therapeutics Cisplatin and Carboplatin are two of the most widely prescribed anticancer agents.
However, not all tumors can be treated with Cisplatin. In addition, Cisplatin may cause an extremely toxic ... More | Tshuva Edit | |
Application
Prolonged epileptic seizures may lead to the development of life threatening cerebral state of a persistent seizure, referred as Status epilepticus (SE).
Oral administration of anti-convulsants antiepileptic drugs (AEDs) as well ... More | Bialer Meir | |
Background
Valproic acid (VPA) is a first line antiepileptic and CNS drug (Epilepsy, neuropathic pain, bipolar disorders etc)
Multivalent action of VPA is highly advantageous, promising improved efficacy with reduced side effects for ... More | Bialer Meir | |
Background:
Autism spectrum disorder (ASD) is one of the fastest growing developmental disability in the United States, represents a group of neurodevelopmental disorders characterized by impaired social interaction and communication as well as ... More | Avraham Yosefa | |
Background
A bipolar disorder is a form of a depressive disease that characteristically involves cycles of depression and elation or mania. The disorder is often a chronic recurring condition deteriorating one’s quality of life.
Valnoctamide ... More | Bialer Meir | |
Background
Emulsification in aqueous media is not effective for the encapsulation of hydrophilic drugs. Peptides and proteins may deteriorate when exposed to aqueous-organic interfaces
Neuropeptides are potent CNS neuromodulators and have many ... More | Domb Abraham | |
Categories:
Life Science & Biotechnology
Technology Keywords:
Nasal administration, CNS active oil, neurodegenerative diseases, CNS
Development Stage:
Formulation and experiments in animals
Patent Status:
US patent application ... More | Touitou Elka | |
Background
Parkinson’s Disease (PD) is a progressive neurodegenerative disease caused by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). As the disease progresses the number of dopaminergic neurons decreases. ... More | Atlas Daphne | |
Background
Parkinson disease (PD) is a long-term, progressive neurodegenerative disorder of the central nervous system, which results in motor and non-motor dysfunction.
The disease is primarily related to loss of dopaminergic ... More | Sharon Ronit | |
Category
LifeSciences and BioTechnology
Keywords
Parkinson’s Disease, PD, Dementia, Diagnostic Kit, Diagnostics, Non-Motor Symptoms, mRNA, Circulating RNA
Current development stage
General list: TRL3 Experimental proof of ... More | Soreq Hermona | |
Category
LifeSciences and BioTechnology
Keywords
epilepsy, rare disease, gene therapy
Current development stage
For pharmaceutical development: TRL4 - POC & Safety of candidate drug formulation is demonstrated in defined animal ... More | Aqeilan Rami | |
Categories
Small molecules, anti-inflammatory treatment
Development Stage
In-vivo proof of concept
Patent Status
Patent application filed
Market
Inflammation indications: acute pancreatitis, acute live damage, fatty liver damage, ... More | Weinstock-Rosin Marta | |
Background
A nonsense mutation is an alteration in the genetic code that prematurely halts the synthesis of an essential protein, such as dystrophin in Duchenne muscular dystrophy. Nonsense mutations caused by premature stop codon, are treated ... More | Karni Rotem | |
Additional information will be provided upon request
More | Domb Abraham |
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