| Technology Name | Briefcase | Lead Researcher |
|---|---|---|
Background
Fatty liver disease - Non alcoholic fatty liver disease (NAFLD) is a continuum of diseases that include simple steatosis and non-alcoholic steatohepatitis (NASH) ultimately leading to cirrhosis, hepatocellular carcinoma (HCC) and/or ... More | Tirosh Oren | |
Background
Many important biochemical compounds and drugs of natural origin contain spirofuranone ring structures (these structures exist among carbohydrates, terpenoids, vitamins, alkaloids, glycosides and antibiotics). All derived from a ... More | Tsvelikhovsky Dmitry | |
Our Innovation
Based on a provocative working hypothesis, we most probably identified the molecular origin of insulin resistance (IR). Systemic IR is induced via post-translational modification (PTM) of liver key regulatory proteins. We ... More | Ben-Sasson Shmuel | |
Background
Oxazine, Azaspirone, Quinolines, Quinolinone, and Quinolinol structures are frequently observed as scaffold segments in various biochemical compounds. These architectures have been identified as building blocks of a numerous ... More | Tsvelikhovsky Dmitry | |
Background
Methylene lactone structures are frequently observed as scaffold segments of various biochemical compounds.
These architectures have been identified as building blocks of numerous terpenoids, as well as other families of diverse ... More | Tsvelikhovsky Dmitry | |
Background
As for today, an oral treatment to metastasis therapy is still an unmet challenge. We discovered a new approach to treat metastatic disease in that was verified in several preclinical models.
Our Innovation
A new approach to treat ... More | Reich Reuven | |
Background
Malaria is caused by unicellular Plasmodium parasites which are transmitted by the bite of mosquitoes. Although several medicines are available for prophylaxis and treatment of acute infection, their application is severely hampered ... More | Dzikowski Ron | |
Additional information will be provided upon request
More | Domb Abraham | |
Wide range of disorders including inflammation, pain, neurological and neurodegenerative diseases, MS, cancer
Categories
Immunology, Inflammation, CNS, Cardiovascular, Small Molecule
Development Stage
Tested in head injury small animal ... More | Mechoulam Raphael | |
New Ti(IV) metal complexes of Salan-ligands for Cancer treatment with reduce side effects (No. 2497)
Background
Metal based anti-tumor therapeutics Cisplatin and Carboplatin are two of the most widely prescribed anticancer agents.
However, not all tumors can be treated with Cisplatin. In addition, Cisplatin may cause an extremely toxic ... More | Tshuva Edit | |
Category
Chemistry & Materials
Keywords
VPA, Epilepsy, Neuropathic Pain and Bipolar Disorder
Current development stage
TRL 4, POC demonstrated, anticonvulsant activity tested in animal modelsApplication
Prolonged epileptic ... More | Bialer Meir | |
Background
Valproic acid (VPA) is a first line antiepileptic and CNS drug (Epilepsy, neuropathic pain, bipolar disorders etc)
Multivalent action of VPA is highly advantageous, promising improved efficacy with reduced side effects for ... More | Bialer Meir | |
Background:
Autism spectrum disorder (ASD) is one of the fastest growing developmental disability in the United States, represents a group of neurodevelopmental disorders characterized by impaired social interaction and communication as well as ... More | Avraham Yosefa | |
Category
Life Sciences and Biotechnology
Keywords
Bipolar disease, Migraine, Schizophrenia, Epilepsy & Neuropathic Pain, antiepileptics, drugs (AEDs), CNS drugs
Current development stage
TRL7- Phase 2 clinical trials ... More | Bialer Meir | |
Keywords
Nanoparticles, Neuropeptides, Intranasal delivery
Current development stage
TRL4 - POC & Safety of candidate drug formulation is demonstrated in defined animal model
Highlights
Emulsification in aqueous media is not effective ... More | Domb Abraham | |
Categories:
Life Science & Biotechnology
Technology Keywords:
Nasal administration, CNS active oil, neurodegenerative diseases, CNS
Development Stage:
Formulation and experiments in animals
Patent Status:
US patent application ... More | Touitou Elka | |
Keywords
Cell death, dopaminergic (DA) neurons, L-Dopa-induced dyskinesia (LID)
Current development stage
TRL3 - hypothesis testing and initial POC demonstrated in limited number of in-vitro models Application
Parkinson’s Disease (PD) is a ... More | Atlas Daphne | |
Keywords
Parkinson’s disease, PD, Central Nervous System, CNS
Current development stage
TRL3 - Hypothesis testing and intial POC demonstrated in limited number of in-vitro models; Our Innovation
Parkinson disease (PD) is a long-term, ... More | Sharon Ronit | |
Categories
Small molecules, anti-inflammatory treatment
Development Stage
In-vivo proof of concept
Patent Status
Patent application filed
Market
Inflammation indications: acute pancreatitis, acute live damage, fatty liver damage, ... More | Weinstock-Rosin Marta | |
Background
Cancer cells lose their epigenetic checks and balances followed by unscheduled shut-off of tumor-suppressor genes and switch-on of genes that promote cell proliferation.
1st generation of anti-cancer epigenetic drugs are ... More | Ben-Sasson Shmuel | |
Categories:
Life sciences & Biotechnology
Technology Keywords:
Muscular dystrophy, nonsense mutation,
Duchenne, Becker, cystic fibrosis, genetic diseases, dystrophin
Development Stage:
Proof of concept
Our Innovation
A nonsense ... More | Karni Rotem | |
Additional information will be provided upon request
More | Domb Abraham | |
Additional information will be provided upon request
More | Domb Abraham |
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