Overview:         

This technology introduces a novel method and apparatus for the solid phase synthesis of peptides that leverages high shear conditions to dramatically improve reaction efficiency.

Key Features & Advantages:

  • High Shear Mixing:
    Utilizes high shear forces , but standard and inexpensive commercial equipment, to promote uniform reagent distribution on the solid support, accelerating reaction kinetics.
  • Unprecedented Speed:
    Shortens reaction times (14AA peptide synthesis in <2 hours vs. 48 hours with conventional methods) without damage to the synthesized peptides  and minimizes side reactions, leading to higher overall yields and improved product purity. Each amino acid coupling cycle completed in ~6 minutes
  • Superior Economics:
    Suitable for both small-scale research applications (e.g., peptide synthesis, combinatorial chemistry) and industrial-scale production of pharmaceuticals and specialty chemicals.
    • 90% reduction in raw material usage
    • Equipment cost 98% lower than competing systems ($1,500 vs. $100,000)
    • Minimal waste generation
    • Reduced solvent consumption
    • Equimolar-level efficiency
    • 95% crude peptide purity
    • No racemization even at high temperatures
    • High coupling efficiency
  • Process Optimization and Scalability:
    Allows fine-tuning of reaction parameters to achieve optimal synthesis conditions for a wide range of organic compounds.
    • Readily scalable to industrial production
    • 5g scale synthesis achieved in 3 hours with 95% purity
    • Compatible with standard chemical industry equipment
    • No specialized facilities required
  • Broad patents granted

Market Potential & Applications:

  • Pharmaceutical Manufacturing:
    Faster, more efficient synthesis of peptides, therapeutic proteins, and small-molecule drugs.
  • Chemical & Biotech Industries:
    Streamlined processes for producing complex organic molecules, offering cost savings and improved scalability.
  • Research & Development:
    Enables rapid synthesis and prototyping in academic and industrial laboratories, accelerating innovation in organic and medicinal chemistry.

Licensing Opportunity:

This patented technology offers a significant competitive advantage by increasing synthesis efficiency and product quality. It presents an attractive licensing opportunity for companies in the pharmaceutical, chemical, and biotech sectors looking to enhance their manufacturing processes and reduce production costs.

Next Steps:

For further technical details, discussions on potential collaboration, and licensing opportunities.