| Categories | Biofilm, anti-biofilm, anti-biofilm peptides, antiseptic agent, disinfectant agents, antibacterial agents, antimicrobial agent, chemical disinfectants, biocides. |
| Development Stage | Pre-clinical proof of concept and initial results |
Our Innovation
We have developed an environmentally-friendly, non-toxic peptide-based mixture which can serve as an antibacterial cleaning agent for killing many types of bacteria rapidly, and efficiently degrading mature biofilm structures.
These easily-synthesized compounds offer a low-cost alternative to chlorine-based and other chemical disinfectants. Excessive use of such chemicals results in highly-resistant bacteria that form biofilms
Technology
The agent consists of a synthesized cocktail of 20-mer random-sequenced peptide mixture.
This random-sequenced peptide mixture demonstrated far more effective anti-biofilm activity towards antibiotic-resistant bacteria, as compared to specific sequence anti-biofilm peptides. Based on what we showed using scanning electron microscopy, we hypothesize that these compounds are able to penetrate the extra-cellular matrix of bacterial biofilm, and kill the bacteria inside the biofilm structure.
Benefits
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Highly active agent kills bacterial cells and destroys biofilms rapidly and effectively
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Non-toxic, environmentally-friendly biological agent
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Does not require purification, easier and cheaper than synthesizing sequence-specific peptides
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Highly efficient, requires low concentration to kill vast amounts of bacteria
Development Milestones
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The compounds showed strong and broad antimicrobial activity.
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The compounds showed effective anti-biofilm activity.
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We are studying the toxicity of our compounds on mouse models.
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The agent showed low toxicity towards human embryonic kidney cells.
Applications
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Disinfectant and cleaning agent
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Hospital environments
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Biomedical devices
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Dentistry equipment
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Biofouling buildup on marine vessels
Researcher information: http://departments.agri.huji.ac.il/biochemfoodsci722/teachers/zvi_hayouka/
PATENT STATUS
Granted US 11,103,547
