|Categories||Biofilm, anti-biofilm, anti-biofilm peptides, antiseptic agent, disinfectant agents, antibacterial agents, antimicrobial agent, chemical disinfectants, biocides.|
|Development Stage||Pre-clinical proof of concept and initial results|
We have developed an environmentally-friendly, non-toxic peptide-based mixture which can serve as an antibacterial cleaning agent for killing many types of bacteria rapidly, and efficiently degrading mature biofilm structures.
These easily-synthesized compounds offer a low-cost alternative to chlorine-based and other chemical disinfectants. Excessive use of such chemicals results in highly-resistant bacteria that form biofilms
The agent consists of a synthesized cocktail of 20-mer random-sequenced peptide mixture.
This random-sequenced peptide mixture demonstrated far more effective anti-biofilm activity towards antibiotic-resistant bacteria, as compared to specific sequence anti-biofilm peptides. Based on what we showed using scanning electron microscopy, we hypothesize that these compounds are able to penetrate the extra-cellular matrix of bacterial biofilm, and kill the bacteria inside the biofilm structure.
Highly active agent kills bacterial cells and destroys biofilms rapidly and effectively
Non-toxic, environmentally-friendly biological agent
Does not require purification, easier and cheaper than synthesizing sequence-specific peptides
Highly efficient, requires low concentration to kill vast amounts of bacteria
The compounds showed strong and broad antimicrobial activity.
The compounds showed effective anti-biofilm activity.
We are studying the toxicity of our compounds on mouse models.
The agent showed low toxicity towards human embryonic kidney cells.
Disinfectant and cleaning agent
Biofouling buildup on marine vessels
Researcher information: http://departments.agri.huji.ac.il/biochemfoodsci722/teachers/zvi_hayouka/
Granted US 11,103,547